Achieving zero emissions across transportation is a tremendous challenge. The upcoming Euro 7/VII standards, set to be enforced in 2025, will mandate further reduction in ICEs exhaust emissions. Thus, additional improvements and potential new technologies are needed to bring ultra-low emissions vehicles. Hybrid propulsion powertrains and alternative fueled (syn-fuels, e-fuels, etc.) engines represent bridging technologies for reducing harmful gas emissions (GHG, NOx, PM, etc.) in the medium term, overcoming the main drawbacks of the pure electrified powertrain (BEV, FCEV), especially for heavy-duty vehicles. Hydrogen seems to be a very attractive fuel, thanks to its high lower heating value, clean combustion, and extremely low pollutant emissions, due to the zero-carbon content. Nevertheless, NOx emissions are still an issue in hydrogen fueled engines and optimized lean-burn combustion and suitable after-treatment NOx reduction are mandatory to reach high specific power and efficiency