This study aimed to evaluate the influence of child anthropometry, seat posture (recline and rotation), seatbelt force limiting, and frontal collision scenarios on the kinematic response and injury risk to children in highly automated vehicles. The TUST IBMs 6YO-O model was conducted the frontal collisions in sled tests. This simulation matrix includes five percentiles six-year-old occupants (P3, P25, P50, P75, and P97), three seatback angles (20°, 30°, and 45°), four seat rotation angles (0°, 90°, 180°, and 270°), three seatbelt force limiting (2.6 kN, 3.6 kN, and 4.6 kN), and three collision types. Injury risks were assessed including the child occupant's head, neck, chest/abdomen, and lumbar region in each simulation (n=540). The results indicate that the child anthropometry, the seatback angle, and the seat rotation angle have a significant influence on the motion responses. Statistically significant differences between all the groups within each independent variable category were