A vital aspect of Ultra-Fast Charging (UFC) Li-Ion battery packs is their thermal management system, which directly influences safety, performance, and cell longevity. Immersion cooling technology offers superior effectiveness compared to indirect cold plate cooling, as it allows for faster heat dissipation and has the potential to significantly mitigate thermal runaway propagation, enhance overall pack performance, and extend cell life. To achieve faster design optimization and deeper insights, high-fidelity Multiphysics-Multiscale simulations are essential. In this study, Equivalent Circuit Model (ECM) based electro-thermally coupled CFD simulations are utilized to optimize an innovative busbar design that facilitates the removal of individual cells. Additionally, high-fidelity 3D transient flow-thermal simulations have been employed to optimize coolant flow direction, inlet positions, cell spacing, and separator design, ensuring efficient flow distribution within the module. While