Fused Deposition Modeling (FDM) is a widely recognized additive manufacturing method that is highly regarded for its ability to create complex structures using thermoplastic materials. Thermoplastic Polyurethane (TPU) is a highly versatile material known for its flexibility and durability. TPU has several applications, including automobile instrument panels, caster wheels, power tools, sports goods, medical equipment, drive belts, footwear, inflatable rafts, fire hoses, buffer weight tips, and a wide range of extruded film, sheet, and profile applications.. The primary objective of this study is to enhance the FDM parameters for TPU material and construct regression models that can accurately forecast printing performance. The study involved conducting experimental trials to examine the impact of key FDM parameters, such as layer thickness, infill density, printing speed, and nozzle temperature, on critical responses, including dimensional accuracy, surface quality, and mechanical