The future heavy duty powertrain market is expected to be more diverse, with a gradual shift towards cleaner and more sustainable alternative fuels. Among various options, the hydrogen Internal Combustion Engine (ICE) holds the promise of significantly reducing carbon emissions while leveraging existing ICE technology. However, it also faces substantial challenges related to engine performance, fuel storage and delivery, infrastructure development, economic feasibility, safety and market acceptance. This paper focuses on performance challenges of hydrogen engine, including knock and pre-ignition, as well as low thermal efficiencies, and introduces the Opposed-Piston Two-Stroke Hydrogen ICE (OP2S-H2ICE) as a potential solution. The study demonstrates that OP2S-H2ICE can operate using direct injection, compression-ignition (CI) combustion solely with hydrogen, under various low-load to partial load conditions. Specifically, as the load increases, the combustion transitions from partial