Study examines the energy breakdown from the combustion of a compression ignition, 4-cylinder, 2.2L engine running with mixtures of DME-to-Propane ranging of 100%-0%, 85%-15%, 75%-25%, and 65%-35% by weight. The paper focuses on one the operating point of 2000rpm - 100Nm, important representative points in the FTP certification cycle. For each fuel mixture, conditions tested include sweep of boost, EGR and injection pressure. Tests are conducted at same combustion timing, of CA10 at -1 deg ATDC, with the engine controller operating with a real-time combustion feedback based on in-cylinder sampling of pressure. Trends of NOx, HC, and CO, are similar for range of DME-to-Propane, from 100%-0% to 75%-25%. Boost and injection pressures had the most notable impact on the heat release traces. Higher boost, from stoichiometric to lean resulted in about 3-5% increase on cycle efficiency. Fuel injection pressures resulted in about 1% gain per 200bar. EGR is effective in reducing NOx but has