This paper presents the performances of a modern DI diesel engine, equipped with a Common Rail injection system, fed on blends of an advanced diesel fuel (base fuel) and Diethylene-Glycol-Dimethyl-Ether (Diglyme - C6H14O3). The base fuel was a reformulated diesel fuel with low aromatic and sulfur content. Three blends with different volumetric percentage of Diglyme (10, 20 and 30%) in the base fuel were prepared and tested. The engine was a FIAT M724, installed in a Alfa Romeo 156 1.9 JTD, with a Bosch Common Rail injection system (EDC-15C). At the exhaust of the engine, soot, NOx, HC, CO, and CO2 were measured. The experiments represent the potential of diesel reformulation technology with synthetic fuels coupled with the new diesel technology generation.