Effective cooling of a heated brake system is critical for vehicle safety and reliability. While some flow devices can redirect airflow more favorably for convective cooling, such a change typically accompanies side effects, such as increased aerodynamic drag and inferior control of brake dust particles. The former is critical for fuel efficiency while the latter for vehicle’s soiling and corrosion as well as non-exhaust emissions. These competing objectives are assessed in this study based on the numerical simulations of an installed brake system under driving conditions. The thermal behavior of the brake system as well as aerodynamic impact and brake dust particle deposition on areas of interest are solved using a coupled 3D transient flow solver, PowerFLOW. Typical design considerations related to enhanced brake cooling, such as cooling duct, wheel deflector, and brake air deflector, are characterized to evaluate the thermal, aerodynamic and soiling performance targets. The leading mechanisms relating the changes in cooling airflow and their impact on performance are discussed. In addition, parametric sensitivity and interactions are analyzed in the design scenario. The proposed approach can be leveraged to evaluate the complex design trade-offs for a brake system in any development stage without the need for a physical model or testing.