When the automotive engine cooling fan is actually working, there is a process of interaction and coupling between the fluid and solid domains on the blades. In order to study the influence of the "fluid structure coupling" effect on the aerodynamic and structural performance of fans during operation, a fan performance calculation model was established with and without considering the fluid structure coupling effect of fans. We conducted aerodynamic performance tests on fans, tested the relationship between fan flow rate, static pressure, transmission efficiency and fan speed, and compared and analyzed the calculated fan performance. The aerodynamic performance and structural deformation of the fan were calculated under different flow rates, rotational speeds and environmental temperatures, with and without considering the coupling of fan blades and airflow. The calculation results were compared and analyzed. The calculation results indicate that: (1)The flow rate has a significant impact on the discrepancy in aerodynamic performance with and without FSI included. The larger the flow rate, the greater the error between the calculated and experimental aerodynamic performance values without considering the coupling of fan blades and airflow. (2) The effect of rotational speed on the coupling effect between fan blades and airflow is relatively small, as the deformation is mainly concentrated at the blade tip, with the same deformation direction at the leading and trailing edges and almost no deformation at the blade root and almost no change in attack angle. (3) The temperature has a small impact on the aerodynamic performance under the coupling effect of fan blades and airflow, but has a significant impact on structural deformation. (4) Under high temperature, the deformation of the blade and the stress variation of the support plate are significant, and the support plate may be damaged. The modeling and analysis methods in this article have a certain guiding role in CFD numerical calculation and fluid structure coupling analysis of fluid machinery.