In order to optimize the traffic organization design under the condition of human-vehicle interaction and solve the problem of a lack of intuitive decision-making basis in the existing scheme, this paper proposes an optimization method for traffic organization design based on BIM and simulation technology. Firstly, BIM modeling and parametric expression of traffic space and organizational elements are completed, ensuring the consistency and operability of design information. Secondly, combined with the simulation technology, the key spatial bottlenecks and index selection of multi-scheme dynamic replication are identified, and the advantages and disadvantages of different design schemes are comprehensively evaluated. Then, through the comparison of multiple rounds of simulation and test of the optimization scheme, the key performance indicators are selected for detailed analysis and evaluation. Furthermore, the TOPSIS method is used to analyze the results of each scheme, and the recommended design scheme is finally determined by considering multiple influencing factors. The experimental results show that the combination of BIM and simulation technology can effectively improve the design selection, identify and solve the spatial bottleneck in the design, optimize the traffic flow organization, and provide an important theoretical basis and practical reference for the traffic organization design under the condition of coexistence of people and vehicles. This study provides a framework for the combination of BIM and simulation for traffic organization design under the condition of coexistence of people and vehicles, which has important reference significance for improving the design selection effect and reducing the operation risk.