The body stiffness plays a key role in vehicle performance, such as noise and vibration, ride and handling, durability and so on. In particular, a body D-pillar ring structure is the most sensitive affecting the body stiffness on vehicle with tail gate. Therefore, since D-pillar body ring structure for high stiffness and lightweight is required, an optimized design methodology that simultaneously satisfies the requirements was studied. It focused on a methodology that body engineering designers can optimize design parameters easily and quickly by themselves in the preceding stages of vehicle’s styling distribution and design conceptual planning. First, it is important to establish the body stiffness design strategy by predicting the body stiffness with the vehicle’s styling at early design stage. The methodology to predict body stiffness with the styling and body dimension specification parameters was introduced. Next, design parameters such as a cross-section area, material and thickness of the member, joint structure and detailed shape of the panel were optimized. Finally, the optimized D-pillar structure was applied to the newly developed vehicle and the effect was demonstrated.