The layout of component in the engine compartment affects the fluid flow performance, thereby affects the thermal management performance. Based on the fluid flow performance in the engine compartment of an SUV, this paper proposes local optimization plans of the cooling module—moving downward the oil cooler and forward the intercooler, tilting an angle of the cooling module and shifting the fan. This paper took the fan center temperature as the optimization goal and set three levels for the four factors. It was found that the deviation of the fan has the most significant impact on fan center temperature among four factors. Then we discovered that the interaction between the factors has a significant impact on the air intake volume of the cooling module. Finally, the optimization plans were designed with the goal of increasing the air intake volume of the cooling module and the final optimal plan was determined as the oil cooler was moved down by 150mm, the cooling module was tilted to the left by 2°, the fan was shifted by 50mm to the center, and the intercooler was moved forward by 60mm. Compared with the original layout of the cooling module under the three working conditions, the scheme has optimized the center temperature of the fan by 13.5%, 15.7%, and 11.9%, and the air intake volume has been optimized by 13.0%, 13.2%, and 12.3%, respectively.