A tire is a prominent part of any vehicle, comprising about 33% of the total aerodynamic drag of a vehicle, and is the only part in contact with the road. In this work, an attempt is made to study the aerodynamic characteristics of a non-pneumatic tire (NPT) with hexagonal spokes (HS) in rotating conditions using SimScale® computational fluid dynamics (CFD). The effect of various parameters like camber angle, steering angle, and velocity on the aerodynamic performance is evaluated through coefficients of drag and lift. The results are compared with that of the static condition at zero yaw and zero camber to understand the effect of a rotating wheel on aerodynamic performance. Results show that the increase in the camber angle or steering angle results in reduced drag and lift coefficients. At a vehicle velocity of 40 km/h, Cd value has reduced by 24.17%, 19.81%, and 31.33% for a 1.5° camber angle, 15° steering angle, and combined case with 1.5° camber and 15° steering angles, respectively, from the actual value of 0.9098. Also, for a vehicle velocity of 60 km/h, the drag coefficient is reduced by 8.64% from the actual value of 0.98.