Material Identification using Successive Response Surface Methodology, with Application to a Human Femur Subjected to Three-Point Bending Loading

Material and structural properties of human tissues under impact loading are needed for the development of physical and computational models used in pedestrian and vehicle occupant protection. Obtaining these global properties directly from the data of biomechanical tests is a challenging task due to nonlinearities of tissue-test setup systems. The objective of this study was to develop subject-specific finite element (FE) techniques for material identification of human tissues using Successive Response Surface Methodology. As example, the test data of a human femur in three-point bending is used to identify parameters of cortical bone. Good global and local predictions of the optimized FE model demonstrate the utility and effectiveness of this new material identification approach.