The development of the economy and the associated growth in trade both within the country and international transport, the associated construction and development of transport routes using elements of intelligent transport systems constantly require increasing the efficiency of trunk transportation. In addition, the development of new economic regions with an undeveloped road network is impossible without high-capacity motor vehicles and cross-country ability. To achieve these goals, the creation of active road trains, including multi-link ones, based on non-traditional technical solutions, is required. The idea of using multi-link trains in the system of intercity and international transportation is not new. However, at the present stage of development of automotive technology requires rethinking and use of new achievements of science and technology. At present, the process of changing the design of land vehicles, qualitatively changing their structure and composition of the main power devices based on the integration of electronic, electrical, hydraulic, pneumatic and mechanical elements and significantly increasing the role of electronics and control systems, i.e. widespread introduction of mechatronic systems and modules in the design of a road train. The article describes some aspects of constructing the transmission of active road trains based on the mechatronic modular principle. Materials of the article are based on the results of theoretical and experimental studies conducted by the authors and with their participation. In this article, the term “mechatronics” is understood as a synthesis of electromechanics and microelectronics, combined by a common control and optimized according to system-wide criteria.