Light commercial vehicles are an indispensable element for the transport of people and the delivery of goods, especially on extra-urban and long-distance routes. With a view to sustainable mobility, it is necessary to think about hybridizing these vehicles to reduce the fuel consumption as well as greenhouse gas emissions and particulate matter. These types of vehicles are generally powered by diesel and travel many kilometers a day. On the other hand, the use of light commercial vehicles in battery electric vehicle (BEV) configuration has already been started but is not receiving widespread recognition. In this panorama, starting from a study already developed for the hybridization of a plug-in light commercial vehicle in Worldwide harmonized Light vehicles Test Cycle (WLTC) condition, the simulation analysis has been extended to the plug-in hybrid vehicle (PHEV) operating in real driving emission conditions (RDE). In particular, using Advisor software, a vehicle has been simulated in different plug-in hybrid configurations. The software has been validated with real operation data of a euro 6 diesel engine. The general hypothesis underlying the research consists in the possibility of using these vehicles in totally electric mode in the city and in hybrid mode outside urban centers; with the aim of reducing polluting emissions in populated city but completing the delivery mission during all phases of vehicle operation. The PHEV simulations have been performed on both WLTC and RDE condition. In the latter mode, particular attention has been devoted to the interpretation of data from GPS sensor: like the slope of the route or the presence of tunnels. The success of the simulation depends on a correct and careful reconstruction of the GPS data. Three vehicles with different hybridization factors have been simulated: 0.44, 0.56, and 0.67, respectively, with power equal to that of the base vehicle. The battery packs have been sized for the three hybrid vehicles and simulations were carried out in both Charge Depleting and Charge Sustaining configuration. In charge depleting for the highest hybrid configuration (HF=0.66), the results demonstrate that a reduction of up to 80% and 76% in fuel can be saved While a reduction up to 75% and 45% in NOx emissions can be achieved on WLTC and RDE cycle, respectively. On the other hand, when the battery is discharged, for HF=0.67, although consumption can be reduced by up to 45%, NOx emissions also increase by 183% even if ICE operation mode has to be better optimize for hybrid operation. Finally, even if the hybrid solutions is really convenient if compared to the conventional vehicle in terms of fuel savings and NOx pollutant emissions, about a realistic estimation of the CO2 reduction that can be achieved the use of electrical energy must be take into account.