By the early 2020s, more than 4.5 billion people have been living in urban areas worldwide, compared to just 1 billion in 1960. Rising growth in urban populations present challenges to infrastructure and transportation systems. Higher traffic levels and reliance on conventional vehicles have contributed to heightened greenhouse gas (GHG) emissions, rising global temperatures, and irreversible environmental degradation. In response, emerging transportation solutions—including intelligent ridesharing, autonomous vehicles, zero-tailpipe-emission transport, and urban air mobility—offer opportunities for safer and more sustainable transportation ecosystems. However, their widespread adoption depends not only on technological performance and efficiency, but also on integration with current infrastructure, safety, resilience to unexpected disruptions, and economic viability. A dynamic, agent-based System-of-Systems (SoS) transportation model is developed to simulate vehicle traffic and human movement, for assessing mobility solutions against different demand scenarios, and possible disruptions within a well-defined metropolitan area. The analysis adopts the concept of an airport city—a cluster of residential, commercial, and industrial spaces surrounding major airports—as a representative urban context. Using the Atlanta Aerotropolis as a case study, this work introduces an interactive, parametric decision-support methodology for evaluating the impact and benefits of future mobility options, as part of transportation master planning. Given the multi-objective and multi-stakeholder nature of transportation planning (e.g. local government, urban planners, engineers, technology providers, etc.), the proposed approach leverages simulation-enabled digital twins of mobility solution alternatives to analyze traffic performance across multiple criteria, including energy consumption, emissions, affordability, accessibility, and connectivity within the broader urban infrastructure. The study reveals cost-benefit trade-offs among mobility solutions in the context of disruptive scenarios, such as the 2026 FIFA World Cup hosted by Atlanta, GA. The results highlight the importance of deploying a mix of mobility options over the city’s transportation network to maximize sustainability while maintaining resilient operations.