Advancements in sensor technologies have led to increased interest in detecting and diagnosing "driver states"-collections of internal driver factors generally associated with negative driving performance, such as alcohol intoxication, cognitive load, stress, and fatigue. This is accomplished using imperfect behavioral and physiological indicators that are associated with those states. An example is the use of elevated heart rate variability, detected by a steering wheel sensor, as an indicator of frustration. Advances in sensor technologies, coupled with improvements in machine learning, have led to an increase in this research. However, a limitation is that it often excludes naturalistic driving environments, which may have conditions that affect detection. For example, reductions in visual scanning are often associated with cognitive load (e.g., Angell et al., 2015); however, these reductions can also be related to novice driver inexperience (e.g., Stahl et al., 2019) and alcohol intoxication (e.g., Tivesten et al., 2023). Through our analysis of the research, we discover that the tendency to explore these singular driver states with only a comparison to "normal" driving is common . Additionally, research on interventions for these driver states is relatively scarce (fewer than 10% of cognitive load-related papers we examined assessed or discussed intervention solutions) and narrowly tailored to specific states [e.g., Bennakhi & Safar, 2016, vis-à-vis cognitive load]. States that share common behavioral and physiological markers tend to be explored independently when a more universal and integrated approach may be warranted. In this paper, we identify the need for a driver state and intervention framework that addresses these limitations by exploring state indicators and their overlap, interventions for one or multiple states, and major research gaps. Our framework offers practical approaches for handling one or many driver states, including interventions that may be deployed at different timings during a trip .