A general principle scheme of IEHB (Integrated Electro-Hydraulic Brake system) is proposed, and the working principle of the system is simply introduced in this paper. Considering the structure characteristics of the hydraulic control unit of the system, a kind of time-sharing control strategy is adopted to realize the purpose of independent and precise hydraulic pressure regulation of each wheel brake cylinder in various brake conditions of a vehicle. Because of the strong nonlinear and time varying characteristics of the dynamic brake pressure regulation processes of IEHB, its comprehensive brake performance is mainly affected by temperature, humidity, load change, the structure and control parameters of IEHB, and so on. Under certain temperature, humidity and load conditions, whether the matching of the structure and the control parameters of IEHB is appropriate or not, the brake performance of a vehicle would be affected directly and severely, and then the safe driving of a vehicle could not be guaranteed effectively. In order to enhance the adaptability of the pressure regulating performance of IEHB to external influence factors and improve the comprehensive performance index of IEHB, using the software and hardware test platform of IEHB, combining the robustness optimization design method based on the application of GA (Genetic Algorithm) and modern generalized experiments, the structure and the control parameters of IEHB are matched and optimized. Finally, by comparing the results before and after optimization, it is verified that the pressure regulation of optimized IEHB is more rapid, more accurate and more robust, the comprehensive brake performance is significantly improved, and the new type of brake system could well meet the application requirements of an advanced vehicle chassis control system in the future.