With increasing challenges for optimizing vehicle ride and handling performance along with efficiency, the synergy between major systems such as suspension, chassis, brakes & tires has been investigated in the past. In this regard, the interaction between wheel rim width and tire performance characteristics has become a topic of interest. Extensive research is being conducted in the automotive industry to understand their key interaction dynamics and make appropriate design selections. This study aims to provide a comprehensive analysis of how variations in wheel rim width affect key tire performance parameters such as lateral force characteristics ,damping property, tire footprint, and pinch cut resistance. Also, the subsequent influence on vehicle-level performance parameters such as braking, ride & handling, steering, and durability is captured. Through rig level testing and full-vehicle evaluation data, several key observations have emerged. Firstly, it was observed that narrower wheel rims tend to have reduced rolling resistance in turn offering higher fuel efficiency. However, this comes at the expense of reduced lateral grip and stability during vehicle direction-changing maneuvers. Conversely, wider wheel rims enhance traction and cornering power by providing a broader contact patch between the tire and the road surface. Furthermore, the study shows a deteriorating tire sidewall pinch-cut performance with wider wheels. This is due to the tire mounted on a narrower rim showing uniform energy dissipation along the cavity thus preventing any sidewall cuts during curb impacts. In conclusion, this research shows a deeper perspective on the intricate relationship between wheel rim width and tire performance characteristics which can help vehicle OEMs to make quicker and informed decisions regarding wheel rim width selection to optimize both performance and efficiency while ensuring safe driving