Paper considers the effects of fluid properties from liquified gases during high pressure pumping, at ranges from 200 to 1500 bar, and at speeds of 500 to 1500 rpm. Tests represent highest to date pressure ranges attained with liquified fluids such as DME. The paper examines the effects of compressibility on the pumping and resulting loading torque characteristics described over the pumping cycle as resolved by a high-fidelity sensor. Experimental tests and simulated performance based on a 1-D model are compared for Diesel and DME for a high-pressure fuel pump, piston style, featuring two plunger-barrels. Each of the pump’s plunger-barrel is inlet metered electronically, allowing the pump to run at a variable displacement and with the flexibility to deactivate one or both plungers fully. The model captures the response of the inlet metering valve and output valve lifts across speed and loads. The output check valve is subject to pressure pulsations and shows the importance to optimize its time response to stabilize it and thus provide optimal pumping. The model also captures the torque response, with contributions arising from the pressure loading, spring return force, and acceleration. Torque depends on the volume pumped, which conversely is dependent on pressure and compressibility. The volumetric efficiency is reduced as pressure increases, but the mechanical efficiency of output pressure-work over input torque remains high, between 80-90% in most of the pump operating conditions. Experimental torque measurements show close alignment with the simulations at elevated pump speeds and pressures but differences are noted at lower speeds. The deviations appear to arise from the outlet check valve stability and from the flow dynamics experienced at the pump inlet. These inlet dynamics were not properly captured in the model, but they are notable in the experimental results. Tests show significant variability in the pump pressure feed owing to the flow dynamics. Test results show this variability is reduced when the pump operates with two plunger-barrels rather than one. With one plunger-barrel the torque profile is notably cyclical, a high torque from one plunger is succeeded by a lower toque on the following plunger, while with the two plunger-barrels configuration the torque profile becomes more uniform from one plunger to the next.