This work involves the thermal management of 18650 Li-ion battery pack using a unique single-pass wavy channel heat exchanger, where the cells are arranged in a staggered manner. Effects of various parameters, which were not previously considered together, like discharge rate, the flow rate of the coolant, coolant inlet temperature, and different flow arrangements in the channels on the temperature of the battery pack and pressure drop across the wavy channel are analyzed. Also, the dimensions (height × width) of wavy channel is varied from 35 × 3 mm to 45 × 3 mm to check its effects. Results show that at higher C-rate, higher coolant inlet temperature, and lower flow rate of coolant resulted in higher temperatures of the battery pack. Increasing the dimensions of wavy channel resulted in a reduction in temperature by 9.96%, 10.32%, and 10.03% for flow arrangements 1, 2, and 3, respectively, at 4 C-rate, 5 LPM flow rate, and inlet coolant temperature of 45°C. Similarly, pressure drops of 7.9%, 7.74%, and 7.75% were observed for the same conditions. For both wavy channel models, it was found that by changing from flow arrangement 1 to flow arrangement 2, on an average the maximum temperature in the battery pack reduced by 1.49% and by changing from flow arrangement 1 to flow arrangement 3, on an average the maximum temperature in the battery pack reduced by 0.14%. The pressure drop across the channel remained constant regardless of the flow arrangement.