The paper reviews the CFD optimization of a motorcycle engine, modified for the development of a hybrid powertrain of a Formula SAE car. In a parallel paper, the choice of the donor engine (Ducati 959 Panigale: 2-cylinder, V90, 955 cc, peak power 150 HP at 10500 rpm, peak torque 102 Nm at 9000 rpm) is thoroughly discussed, along with all the hardware modifications oriented to minimize the new powertrain dimensions, weight and cost, and guarantee full reliability in racing conditions. In the current paper, the attention is focused on two main topics: 1) CFD-1D tuning of the modified Internal Combustion Engine (ICE), in order to comply with the Formula SAE regulations, as well as to maximize the power output; 2) simulation of the vehicle in racing conditions, comparison with a conventional combustion car and a full electric vehicle. The stock engine has been strongly modified, since the head of the vertical cylinder has been replaced by the electric motor, and the intake system of the other cylinder now includes a 20 mm restrictor. Despite these constraints, the tuned ICE is able to deliver more than 70 HP. Finally, the study shows that the hybrid car is not only more efficient (-26% of specific CO2), but also 1.48 s faster on each lap than the corresponding Combustion single seater.