Automated Driving Systems (ADS) rely on AI algorithms, machine learning, and sensor fusion to perform autonomous driving tasks. Safety challenges arise due to the probabilistic behavior of AI/ML algorithms and the need to ensure safety within defined Operational Design Domains (ODDs). Traditional standards such as ISO 26262[3] (Functional Safety) and ISO 21448[4] (SOTIF) address hardware and software failures or functional deficiencies but are insufficient for higher-level autonomous systems (SAE Levels 3–5). To close this gap, additional standards such as UL 4600[1] and ISO 5083[2] provide complementary frameworks for ADS safety assurance. UL 4600[1] establishes a claim-based safety case encompassing the vehicle, infrastructure, and processes, emphasizing structured arguments supported by evidence and reasoning. It offers guidance on autonomy functions, V & V, tool qualification, dependability, and safety culture. ISO 5083[2] focuses on design, verification, and validation of ADS, extending safety lifecycles with system-level principles, risk criteria, and validation metrics. It defines the ADS safety case as proof of acceptable safety for specific features and environments, stressing safety-by-design, layered verification, and post-deployment monitoring, including cybersecurity. Together, UL 4600[1] and ISO 5083[2] enable a unified approach to safety assurance, aligning with Functional Safety and SOTIF principles. Their integration helps manufacturers evaluate ADS systematically, demonstrate risk acceptance, and maintain safety throughout the lifecycle.