With the rapid development of the logistics and transportation industry, heavy-duty trucks play an increasingly important role in social life. However, due to the characteristics of large cargo loads, high center of mass and relatively narrow wheelbase, the driving stability of heavy trucks are poor, and it is easy to cause rollover accidents under high-speed driving conditions, large angle steering and emergency obstacle avoidance. To improve the roll stability of heavy trucks, it is necessary to design an active anti-rollover control system, through the analysis of the yaw rate and the load transfer rate of the vehicle, driving states can be estimated during the driving process. Under the intervention of the control system, the lateral transfer rate of heavy trucks can be reduced to correct the driving posture of the vehicle body and reduce the possibility of rollover accidents. At present, anti-rollover control system is mainly based on the differential brake, However, in actual vehicle instability conditions, a single active anti-rollover control system is often difficult to ensure the safety of the vehicle. It also affects the driver's driving intention and occupant's riding comfort, joint coordinated control of multiple systems is required. This paper takes the active steering and differential control system as an example. Coordinated control of the two subsystems of active steering and differential braking, and the system are jointly simulated based on the Simulink/Trucksim platform. The results show that the designed active anti-rollover control system can give full play to the advantages of the active steering and differential braking control system, reduce the vehicle's lateral load transfer rate, reduce the possibility of rollover, and improve the driving safety of the vehicle