In the near to mid-term, hydrogen internal combustion engines (H2-ICE) can be a bridge technology for reducing carbon emissions. A few challenges anticipated under lean-burn H2-ICE operation are the significant drop in turbo-out temperatures, combined with higher water content, and the possible presence of unburned hydrogen in the exhaust, which could have a potential impact on performance and durability of the downstream exhaust aftertreatment system, particularly oxidation and SCR catalysts, as these conditions can suppress low-temperature oxidation activity, perturb Cu-site speciation and redox cycling in SCR catalysts, and exacerbate hydrothermal aging under sustained wet operation. This study examines the impact of excess water and residual hydrogen on Cu-SCR durability, active site chemistry, and stability for the case with and without an upstream oxidation catalyst, through aging tests at 450 °C and 550 °C. Changes in Cu redox cycles were assessed through site quantification using multiple titration techniques to determine the influence of excess H2O and H2 on catalyst performance and aging.