Software-defined vehicle (SDV) platforms are reshaping safety-critical system design by consolidating braking and other motion-control functions on centralized heterogeneous edge compute that also executes physical-AI workloads. This consolidation breaks traditional assumptions of fixed ECUs and simple timing envelopes, complicating assurance of determinism, isolation, and fail-operational behaviour for ASIL-D brake functions. Building on a decentralized brake-by- wire (BbW) architecture with dual controllers, redundant low-voltage power grids, and smart electromechanical brake corner actuators, this paper proposes a systems-level framework for architecting safety-critical functions in AI-enabled SDVs along three dimensions: compute, timing, and isolation. The framework classifies conventional and AI-based functions and maps them to heterogeneous compute classes; defines architectural patterns that combine safety islands, power-domain redundancy, and hardware partitioning to support freedom from interference; and formalizes timing domains and contracts that bound latency, jitter, and failover dynamics across sensors, centralized controllers, and decentralized actuators. The contribution is not a new AI algorithm, but a safety-oriented architectural framework that constrains how AI-enabled functions may be integrated into fail-operational by-wire systems. A BbW case study with edge-resident AI observers and anomaly detectors shows how the framework complements System Analysis Tool (SAT)– based failure modelling and clarifies trade-offs among safety isolation, latency, and AI performance while preserving braking safety guarantees under continuous software evolution.