This device belongs to the field of aviation materials technology and discloses a high-efficiency drilling equipment for manufacturing aviation materials, which includes a bottom plate. The top of the bottom plate is provided with a clamping structure and a positioning structure. The clamping structure includes a second moving plate, a third sliding groove, a second bi-directional screw, a fourth screw block, a clamping plate, and a rubber block. This device can hold materials through a clamping structure and effectively and quickly locate and drill holes through a positioning structure. By rotating the first threaded rod, it can drive the first screw block to move the U-shaped column. During the movement of the U-shaped column, it will drive the second threaded rod to move together. By rotating the second threaded rod, it will drive the second screw block to adjust the height of the connecting plate for drilling holes. By rotating the third threaded rod, it will drive the first moving plate to move, which will facilitate the multi-directional movement of the drill bit, improve the efficiency of drilling, avoid multiple position changes, and be beneficial for practical applications and operations.