Nickel based superalloys have a wide range of applications due to high mechanical strength at high temperatures, fracture toughness and resistance to corrosion. However, because of their outstanding properties, it is considered as the difficult to machine materials. Inconel alloy X-750 is used extensively in rocket-engine thrust chambers. Airframe applications include thrust reversers and hot-air ducting systems along with large pressure vessels are formed from Inconel alloy X-750. Moreover, the comparative analysis of machinability aspect using coated carbide inserts is reported few. The current study explains the machinability investigation on Inconel alloy X-750 superalloys using coated carbides. To collect the experimental data, the L16 experimental design plan is used to experiment with a machining length of 40 mm. Four level of cutting speed (70,120,170,220 m/min), feed rate (0.1, 0.15, 0.2, 0.25 mm/rev) and cutting depth (0.3, 0.4, 0.5, 0.6 mm) are the cutting/machining parameters used. Cutting Forces, surface roughness, flank and crater wear are considered as target functions. With the application of response surface, coupled with desirability analysis, the optimal levels of the combination are determined. With determined optimal levels, tool life study has been carried out to compare the effectiveness of cutting inserts. Finally, the ranges for best cutting conditions are proposed for serial industrial production.