This content is not included in
your SAE MOBILUS subscription, or you are not logged in.
Simulation of Human Head Response to Impact Loading Using Newly Developed Biofidelic Material Models for Brain Tissue
Technical Paper
2011-22-0004
Annotation ability available
Sector:
Language:
English
Abstract
Brain tissue is known to exhibit regional and directional variations in its mechanical response to external loads. Material models traditionally used to simulate brain tissue deformation in the human head have been primarily region independent and limited to isotropic and linear viscoelastic. The primary goal of this research is to develop a biofidelic material model for brain tissue by accounting for the underlying microstructure of the material. A computational and analytical approach was undertaken in our attempt to develop a more realistic material model. Based on the microstructure observed at the neuron level, a mesoscale model was developed which included neurons, glial cells and Cerebro-Spinal Fluid (CSF). A semi-analytical model was first developed using a simplified geometry accounting for separate fiber and matrix (fluid) behavior of the medium. A second computational model was also constructed by developing a representative volume element (RVE) of brain tissue that includes the neurons, glial cells and CSF. Diffusion Tensor Imaging (DTI) was also utilized to capture anisotropy and directional dependence of the tissue on the continuum scale. Using the aforementioned material models, computational simulations were performed to predict the mechanical response of the brain tissue when subjected to a non-penetrating, impact load.
Recommended Content
Authors
Citation
Littlefield, D. and Kulathu, S., "Simulation of Human Head Response to Impact Loading Using Newly Developed Biofidelic Material Models for Brain Tissue," SAE Technical Paper 2011-22-0004, 2011, https://doi.org/10.4271/2011-22-0004.Also In
References
- Abolfathi, N. Naik, A. Sotudeh Chafi, M. Karami, G. Ziejewski, M. 2009 Micromechanical procedure for modeling the anisotropic mechanical properties of brain white matter Computer Methods in Biomechanics and Biomedical Engineering 12 3 249 262
- Al-Bsharat, A. Hardy, W. Yang, K. Khalil, T. et al. “Brain/Skull Relative Displacement Magnitude Due to Blunt Head Impact: New Experimental Data and Model,” SAE Technical Paper 99sc22 1999 10.4271/99sc22
- Anderson, R.W.G. Brown, C.J. Blumbergs, P.C. McLean, J.A. Jones, N.R. 2003 Impact mechanics and axonal injury in a sheep model Journal of Neurotrauma 20 10 961 974
- Bernick, K.B. Prevost, T.P. Suresh, S. Socrate, S. 2010 Mechanical loading of neurons and astrocytes with application to blast traumatic brain injury Proceedings of the 27th Army Science Conference
- Cloots, R. J. H. Van Dommelen, J. A. W. Nyberg, T. Kleiven, S. Geers, M. G. D. 2010 Micromechanics of diffuse axonal injury: influence of axonal orientation and anisotropy Biomechanics and Modeling in Mechanobiology 10 3 413 422
- Garcia, T. Ravani, B. 2003 A biomechanical evaluation of whiplash using a multi-body dynamic model Journal of Biomechanical Engineering 25 254 265
- Graham, D. I. Raghupathi, R. Saatman, K. E. Meaney, D. McIntosh, T.K. 2000 Tissue tears in the white matter after lateral fluid percussion brain injury in the rat: relevance to human brain injury Acta Neuropathologica 99 117 24
- Hill, R. 1963 Elastic properties of reinforced solids: some theoretical principles Journal of Mechanics and Physics of Solids 11 357 372
- Holburn, AHS 1943 Mechanics of head injuries Lancet 2 438 441
- Horgan, J. Gilchrist, M. D. 2004 Influence of FE model variability in predicting brain motion and intracranial pressure changes in head impact simulations International Journal of Crashworthiness 9 4 401 418
- Horgan, T.J. Gilchrist, M.D. 2003 The creation of three dimensional finite element models for simulating impact biomechanics International Journal of Crashworthiness 8 4 353 366
- Kanit, T. Forest, S. Galliet, I. Mounoury, V. Jeulin, D. 2003 Determination of the size of the representative volume element for random composites: statistical and numerical approach International Journal of Solids and Structures 40 3647 3679
- Khoshgoftar, M. Najarian, S. Farmanzad, F. Vahidi, B. Ghomshe, F.T. 2007 A biomechanical composite model to determine effective elastic moduli of the CNS gray matter American Journal of Applied Sciences 4 11 918 924
- Kulathu, S. 2010 Development of a multiscale material model for brain tissue and its application to the impact response of the human head Ph.D. Dissertation University of Alabama Birmingham
- Miller, K. Chinzei, K. Orssengo, G. Bednarz, P. 2000 Mechanical properties of brain tissue in-vivo: experiment and computer simulation Journal of Biomechanics 33 1369 1376
- Nahum, A. Smith, R. Ward, C. “Intracranial Pressure Dynamics During Head Impact,” SAE Technical Paper 770922 1977 10.4271/770922
- Noh, W.F. Woodward, P. 1976 SLIC (Simple Line Interface Calculation) Proceedings of Fifth International Conference on Numerical Methods in Fluid Dynamics Twente University Enschede
- Prange, M. T. Margulies, S. S. 2002 Regional, directional, and age dependent properties of the brain undergoing large deformation Journal of Biomechanical Engineering 124 244 52
- Rang, E. M. Lippert, S.A. Grimm, M.J. 2001 The degradation of the material properties of brain tissue as a function of time postmortem Bioengineering Conference ASME 50
- Ruan, J. Khalil, T. King, A. 1994 Dynamic head response of the head to impact by three dimensional finite element analysis Journal of Biomechanical Engineering 116 44 50
- Yang, K.H. King, A.I. 2003 A limited review of finite element models developed for brain injury biomechanics research International Journal of Vehicle Design 32 1/2
- Zhang, L. Yang, K. Dwarampudi, R. Omori, K. Li, T. Chang, K. Hardy, W. Khalil, T. King, A. 2001 Recent advances in brain injury research: A new human head model development and validation Stapp Car Crash Journal 45 369 393
- Zhang, L. Yang, K.H. King, A.I 2001 Comparisons of brain responses between frontal and lateral impacts by finite element modeling Journal of Neurotrauma 18 1 21 30
- Zhou, C. Khalil, T. King, A. 1995 A new model comparing impact responses of the homogeneous and inhomogeneous human brain Proceedings of 39th Stapp Car Crash Conference 121 137