Why Standardization Matters in Pulsed Electric Field Generation for Clinical Electroporation

Pulsed field ablation (PFA) is a nonthermal method of tissue ablation technology that uses high amplitude pulsed electrical fields (PEF) to create irreversible electroporation (IRE) in tissues. Unlike traditional thermal ablation technologies, PFA does not rely on heating to damage and destroy tissue. Instead, PFA creates nanopores in cell membranes due to transient, high-voltage exposure that disrupts cell wall integrity, which leads to cell death.1