Solvent/Non-Solvent Sintering To Make Microsphere Scaffolds

A solvent/non-solvent sintering tech- nique has been devised for joining poly- meric microspheres to make porous matri- ces for use as drug-delivery devices or scaf- folds that could be seeded with cells for growing tissues. Unlike traditional sinter- ing at elevated temperature and pressure, this technique is practiced at room tem- perature and pressure and, therefore, does not cause thermal degradation of any drug, protein, or other biochemical with which the microspheres might be loaded to impart properties desired in a specific application. Also, properties of scaffolds made by this technique are more repro- ducible than are properties of comparable scaffolds made by traditional sintering.