New Microscope Uses Adaptable Mirror to Create Clearer Images

The National Institute of Biomedical Imaging and Bioengineering (NBIB) has developed a microscope that increases resolution and contrast in thick biological samples. The new microscope improves on its predecessor by combining two-photon laser scanning microscopy (2PM) with instant structured illumination microscopy (ISIM). Key to the development, was including adaptive optics (AO) to rapidly correct distortions.