Microfabrication of a High-Throughput Nanochannel Delivery/Filtration System

TBMG-11868

11/01/2011

Abstract
Content

A microfabrication process is proposed to produce a nanopore membrane for continuous passive drug release to maintain constant drug concentrations in the patient’s blood throughout the delivery period. Based on silicon microfabrication technology, the dimensions of the nanochannel area, as well as microchannel area, can be precisely controlled, thus providing a steady, constant drug release rate within an extended time period. The multilayered nanochannel structures extend the limit of release rate range of a single-layer nanochannel system, and allow a wide range of pre-defined porosity to achieve any arbitrary drug release rate using any preferred nanochannel size. This membrane system could also be applied to molecular filtration or isolation. In this case, the nanochannel length can be reduced to the nanofabrication limit, i.e., 10s of nm.

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Citation
"Microfabrication of a High-Throughput Nanochannel Delivery/Filtration System," Mobility Engineering, November 1, 2011.
Additional Details
Publisher
Published
Nov 1, 2011
Product Code
TBMG-11868
Content Type
Magazine Article
Language
English