Magazine Article

Live-Cell Microscopy and Traction Force Measurements with Simulated Microgravity “Clinochip”

TBMG-23001

10/01/2015

Abstract
Content

The deleterious effects of microgravity are undeniable: reduced bone mineral density, muscle atrophy, vascular remodeling, etc. These health issues may derive from both systemic factors, and from direct alterations to intracellular components and in the local microenvironment around cells. To understand the biological mechanisms at play, detailed studies have been performed in spaceflight. However, because experiments on the International Space Station (ISS) can be prohibitively expensive, clinostats are an alternative ground-based analogue for cellular studies. Clinostats “randomize” the orientation of gravity with respect to the cell fixed-frame, thereby simulating microgravity by eliminating a preferential gravity direction.

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Citation
"Live-Cell Microscopy and Traction Force Measurements with Simulated Microgravity “Clinochip”," Mobility Engineering, October 1, 2015.
Additional Details
Publisher
Published
Oct 1, 2015
Product Code
TBMG-23001
Content Type
Magazine Article
Language
English