Detergent-Specific Membrane Protein Crystallization Screens

TBMG-2090

08/01/2007

Abstract
Content

A suite of reagents has been developed for three-dimensional crystallization of integral membranes present in solution as protein-detergent complexes (PDCs). The compositions of these reagents have been determined in part by proximity to the phase boundaries (lower consolute boundaries) of the detergents present in the PDCs. The acquisition of some of the requisite phase-boundary data and the preliminary design of several of the detergent- specific screens was supported by a NASA contract. At the time of expiration of the contract, a partial set of preliminary screens had been developed. This work has since been extended under non-NASA sponsorship, leading to near completion of a set of 20 to 30 different and unique detergent-specific 96-condition screens.

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Citation
"Detergent-Specific Membrane Protein Crystallization Screens," Mobility Engineering, August 1, 2007.
Additional Details
Publisher
Published
Aug 1, 2007
Product Code
TBMG-2090
Content Type
Magazine Article
Language
English