Combinatorial Drug Design Augmented by Information Theory
TBMG-3105
04/01/2002
- Content
A proposed method of designing antiviral drugs provides for the utilization of combinatorial-chemistry techniques that have been used previously for this purpose, in conjunction with applicable principles of information theory. In its information-theoretic aspect, the method can be characterized as one of maximizing the mutual information between (1) ensembles of drugs and (2) ensembles of viruses that one seeks to combat by use of the drugs (denoted in the art as targets). The method would entail increases in the time and cost of development of drugs, but these disadvantages could be offset by reduction or prevention of the emergence of drug-resistant viral populations.
- Citation
- "Combinatorial Drug Design Augmented by Information Theory," Mobility Engineering, April 1, 2002.