This work deals with the design and multi-parametric investigation on the uniquely designed propeller for a Pentacopter Unmanned Aerial Vehicle (UAV). The primary and secondary design data along with the performance coefficients such as diameter of the propeller, pitch angle, chord length, lift coefficient are determined through standard analytical approach. About ten different airfoils, namely NACA 2412, NACA 4109, NACA 4312, NACA 4409, NACA 4415, NACA 5317, NACA 6409, NACA 6412, NACA 23024, NACA 25012 with 13 Reynolds Number and an Angle of Attack (AOA) of 20 ranges between -5 to 15 degrees are compared to design the propellers. The lift and drag coefficient values of ten different airfoils using the 13 Reynolds Number and the 20 AOAs are acquired from the XFOIL software. Based on the effect of high Lift-to-Drag (L/D) ratio, three advanced airfoils are chosen among ten relevant airfoils. The shortlisted airfoils provided by means of high L/D ratio are as follows NACA 6409, NACA 4109, and NACA 4312. With the help of advanced modelling tool, the shortlisted three airfoils based four propellers are modelled. The four modelled propellers include Hybrid propeller which is the incorporation of three airfoils, and three propellers with only NACA 6409, NACA 4109, and NACA 4312 airfoils respectively. In ANSYS R2 2023 software, the four propellers are analyzed in a Single moving reference frame method that produces an efficient simulation for rotating frame in computational fluid dynamics methods by providing suitable boundary conditions. It is then computed using Fluid-structure interaction approach simulations with Carbon Fiber Reinforced Polymer (CFRP) and Glass Fiber Reinforced Polymer (GFRP) materials where eight different materials that include Boron Fiber Reinforced Polymer, HMS-CFRP, AS-CFRP, S-GFRP, E-GFRP, GY-70-CFRP, K-49-UD-FRP and T-300-CFRP from which Hybrid propeller is identified as the best performer, especially when imposed with GY-70-CFRP materials in perspective of reduced total deformation when subjected to high loads. This chosen propeller is characterized by lesser torque, directly relating to lesser power consumption during operation while all other propellers exhibit other similar performance parameters with respect to the applications involved for the Pentacopter UAV.