The Hermes Project is currently in the process of developing Hermes-Crew Integration requirements which consider functional, integration and operational features of human factors, human-machine interfaces, crew performance and operation capability aspects. The Hermes system shall define concepts related to crew dedicated elements, such as crew accommodation and habitability architecture, operational environment, and survival provisions, taking into account the Hermes-Crew Integration requirements. The functional requirements relate to a selected group of crew members and to identified roles and functions of these crew members as required by the Hermes Spaceplane System Design. Anthropometric dimensions, e.g. sitting height, eye hight from seat upright, distance from buttock to knee, and functional reach, are required as design factors for all crew systems and equipment. Values for dynamic anthropometric dimensions, neutral body posture and visual field, as well as requirements based on relevant human performance criteria are also considered. The physical environment of the habitable volumes shall have a quality compatible with the performance requirements for the crew, and values related to atmosphere composition and pressure, as well as other environmental aspects are given for nominal, degraded and emergency modes. Particular emphasis is given to life management of the crew, which consists of health management, food services, personal items and operational aids.