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A Sterile Water for Injection System (SWIS) for Use in the Production of Resuscitative Fluids Aboard the Space Station
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Abstract
In an effort to reduce the weight of medical supplies that must be sent into space to support the Health Maintenance Facility (HMF) of the Space Station, a disposable cartridge (SWIS) is being developed which will purify the Space Station potable water to USP XXI(1) Water for Injection (WFI) quality. This water will subsequently be mixed with concentrates to reconstitute intravenous solutions such as Ringer's Lactate, which would be used in emergency situations for treatment of ill or injured crew members. The SWIS purification process train will consist of particulate prefiltration, carbon adsorption, mixed bed deionization, ultrafiltration, and sterilizing microfiltration. The present concept envisions a device that will be passive in nature, requiring only tap pressure as the driving force for filtration. The SWIS is being designed to produce at least 6 liters of WFI at a flow rate of 6 liters/hour. This paper presents performance data on removal capabilities for specific contaminants, namely, residual halogen (disinfectant, iodine), total dissolved solids (TDS), total organic carbon (TOC), bacteria, and bacterial endotoxin. In addition, design features of the cartridge will be discussed.
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Authors
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Citation
Dunleavy, M. and Jha, A., "A Sterile Water for Injection System (SWIS) for Use in the Production of Resuscitative Fluids Aboard the Space Station," SAE Technical Paper 881016, 1988, https://doi.org/10.4271/881016.Also In
References
- United States Pharmacopeia XXI United States Pharmacopeial Convention, Inc. 1985
- Hitt. A. J. III Renfro, R. H. Schien K. F. Streams, E. “Space Station Water Management and Water Reclamation System Testing” Proceedings - Ultrapure Water Journal's Second Annual High Purity Water Conference and Exposition March 1988
- NASA-STD-3000 IV Man/Systems Integration Standard
- “Guideline on Sterile Drug Products Produced by Aseptic Processing” Center for Drugs and Biologics and Office of Regulatory Affairs, Food and Drug Administration June 1987