The electro-mechanical brake booster (EMBB) and hydraulic control unit (HCU) constitute the electro-mechanical brake system, which can meet the requirements of brake system for intelligent vehicles. It does not need vacuum source, provides active braking function, have high control accuracy and fast response. But it has two electronic control units (ECU), which need coordinated control. When ABS is triggered, the pressure of the master cylinder keeps rising and falling, and the pressure fluctuates greatly. This will lead to noise and reduce the durability of the system. In this paper, a pressure optimization control strategy under ABS condition is proposed. Firstly, the structure and control strategy of EMBB are introduced. Secondly, the braking characteristics without pressure optimization control are analyzed. Thirdly, based on the demand of maximum cylinder pressure, a three-closed-loop pressure optimization control strategy is established. Finally, based on the Hardware-In-the-Loop platform, the control strategy is verified. HIL test shows that the strategy can effectively reduce the pressure fluctuation of the master cylinder when triggered by ABS, while ensuring the control performance of ABS.