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A Reanalysis of Experimental Brain Strain Data: Implication for Finite Element Head Model Validation
Technical Paper
2018-22-0007
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English
Abstract
Relative motion between the brain and skull and brain deformation are biomechanics aspects associated with many types of traumatic brain injury (TBI). Thus far, there is only one experimental endeavor (Hardy et al., 2007) reported brain strain under loading conditions commensurate with levels that were capable of producing injury. Most of the existing finite element (FE) head models are validated against brain-skull relative motion and then used for TBI prediction based on strain metrics. However, the suitability of using a model validated against brain-skull relative motion for strain prediction remains to be determined. To partially address the deficiency of experimental brain deformation data, this study revisits the only existing dynamic experimental brain strain data and updates the original calculations, which reflect incremental strain changes. The brain strain is recomputed by imposing the measured motion of neutral density target (NDT) to the NDT triad model. The revised brain strain and the brain-skull relative motion data are then used to test the hypothesis that an FE head model validated against brain-skull relative motion does not guarantee its accuracy in terms of brain strain prediction. To this end, responses of brain strain and brain-skull relative motion of a previously developed FE head model (Kleiven, 2007) are compared with available experimental data. CORrelation and Analysis (CORA) and Normalized Integral Square Error (NISE) are employed to evaluate model validation performance for both brain strain and brain-skull relative motion. Correlation analyses (Pearson coefficient) are conducted between average cluster peak strain and average cluster peak brain-skull relative motion, and also between brain strain validation scores and brain-skull relative motion validation scores. The results show no significant correlations, neither between experimentally acquired peaks nor between computationally determined validation scores. These findings indicate that a head model validated against brain-skull relative motion may not be sufficient to assure its strain prediction accuracy. It is suggested that a FE head model with intended use for strain prediction should be validated against the experimental brain deformation data and not just the brain-skull relative motion.
Authors
- Zhou Zhou - Neuronic Engineering, KTH Royal Institute of Technology, Sto
- Xiaogai Li - Neuronic Engineering, KTH Royal Institute of Technology, Sto
- Svein Kleiven - Neuronic Engineering, KTH Royal Institute of Technology, Sto
- Chirag S. Shah - Humanetics Innovative Solutions, Inc., Farmington Hills, MI,
- Warren N. Hardy - Virginia Tech-Wake Forest Center for Injury Biomechanics, Bl
Citation
Zhou, Z., Li, X., Kleiven, S., Shah, C. et al., "A Reanalysis of Experimental Brain Strain Data: Implication for Finite Element Head Model Validation," SAE Technical Paper 2018-22-0007, 2018, https://doi.org/10.4271/2018-22-0007.Data Sets - Support Documents
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References
- Adams , J. , Graham , D. , and Gennarelli , T. 1981 Acceleration induced head injury in the monkey. II. Neuropathology Experimental and Clinical Neuropathology 26 28 Springer
- Al-Bsharat , A.S. , Hardy , W.N. , Yang , K.H. , Khalil , T.B. , Tashman , S. , and King , A.I. 1999 Brain/skull relative displacement magnitude due to blunt head impact: new experimental data and model Proc. 43rd Stapp Car Crash Conference 321 332 Society of Automative Engineers Warrendale, PA
- Alshareef , A. , Giudice , J.S. , Forman , J. , Salzar , R.S. , and Panzer , M.B. 2017 A Novel Method for Quantifying Human In Situ Whole Brain Deformation Under Rotational Loading Using Sonomicrometry Journal of Neurotrauma 35 5 780 789
- Baeck , K. 2013
- Bayly , P. , Cohen , T. , Leister , E. , Ajo , D. , Leuthardt , E. , and Genin , G. 2005 Deformation of the human brain induced by mild acceleration Journal of Neurotrauma 22 8 845 856
- Bradshaw , D. , and Morfey , C. 2001 Pressure and shear response in brain injury models Proc. 17th International Technical Conference on the Enhanced Safety of Vehicles National Highway Traffic Safety Administration Amsterdam, The Netherlands
- Chafi , M.S. 2009
- Chafi , M.S. , Dirisala , V. , Karami , G. , and Ziejewski , M. 2009 A finite element method parametric study of the dynamic response of the human brain with different cerebrospinal fluid constitutive properties Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 223 8 1003 1019
- Chason , J. , Hardy , W. , Webster , J. , and Gurdjian , E. 1958 Alterations in cell structure of the brain associated with experimental concussion Journal of Neurosurgery 15 2 135 139
- DiMasi , F.P. , Eppinger , R.H. , and Bandak , F.A. 1995 Computational analysis of head impact response under car crash loadings Proc. 39th Stapp Car Crash Conference 425 438 Society of Automative Engineers Warrendale, PA
- Donnelly , B.R. , Morgan , R.M. , and Eppinger , R.H. Durability, repeatability and reproducibility of the NHTSA side impact dummy Proc. 27th Stapp Car Crash Conference 299 310 Society of Automotive Engineers San Diego, CA
- Drake , A.M. , Takhounts , E.G. , and Hasija , V. 2017 Investigation of parameters affecting brain model validation and brain strains using the SIMon finite element head model Proc. IRCOBI Conference 410 431 Antwerp, Belgium
- Feng , Y. , Abney , T.M. , Okamoto , R.J. , Pless , R.B. , Genin , G.M. , and Bayly , P.V. 2010 Relative brain displacement and deformation during constrained mild frontal head impact Journal of The Royal Society Interface 7 53 1677 1688
- Gehre , C. , Gades , H. , and Wernicke , P. Objective rating of signals using test and simulation responses Proc. 21st International Technical Conference on the Enhanced Safety of Vehicles National Highway Traffic Safety Administration Stuttgart, Germany
- Gennarelli , T. , Adams , J. , and Graham , D. 1981 Acceleration induced head injury in the monkey. I. The model, its mechanical and physiological correlates Experimental and Clinical Neuropathology 23 25 Springer
- Gennarelli , T.A. , Thibault , L.E. , Adams , J.H. , Graham , D.I. , Thompson , C.J. , and Marcincin , R.P. 1982 Diffuse axonal injury and traumatic coma in the primate Annals of Neurology 12 6 564 574
- Giordano , C. , Cloots , R. , Van Dommelen , J. , and Kleiven , S. 2014 The influence of anisotropy on brain injury prediction Journal of Biomechanics 47 5 1052 1059
- Giordano , C. , and Kleiven , S. 2014 Evaluation of axonal strain as a predictor for mild traumatic brain injuries using finite element modeling Stapp Car Crash Journal 58 29 61
- Giordano , C. , and Kleiven , S. 2016 Development of an unbiased validation protocol to assess the biofidelity of finite element head models used in prediction of traumatic brain injury Stapp Car Crash Journal 60 363 471
- Guettler , A. , Ramachandra , R. , Bolte , J. , and Hardy , W. 2018 Kinematics Response of the PMHS Brain to Rotational Loading of the Head: Development of Experimental Methods and Analysis of Preliminary Data SAE Technical Paper: 2018-01-0547
- Gurdjian , E.S. , Lissner , H. , Evans , F. , Patrick , L. , and Hardy , W. 1961 Intracranial pressure and acceleration accompanying head impacts in human cadavers Surgery, Gynecology and Obstetrics 113 185 190
- Hardy , W.N. 2002 Instrumentation in experimental design In Accidental Injury 12 39 Springer
- Hardy , W.N. 2007
- Hardy , W.N. , Foster , C.D. , Mason , M.J. , Yang , K.H. , King , A.I. , and Tashman , S. 2001 Investigation of head injury mechanisms using neutral density technology and high-speed biplanar X-ray Stapp Car Crash Journal 45 337 368
- Hardy , W.N. , Khalil , T.B. , and King , A.I. 1994 Literature review of head injury biomechanics International Journal of Impact Engineering 15 4 561 586
- Hardy , W.N. , Mason , M.J. , Foster , C.D. , Shah , C.S. , Kopacz , J.M. , Yang , K.H. , King , A.I. , Bishop , J. , Bey , M. , and Anderst , W. 2007 A study of the response of the human cadaver head to impact Stapp Car Crash Journal 51 17
- Ho , J. , Zhou , Z. , Li , X. , and Kleiven , S. 2017 The peculiar properties of the falx and tentorium in brain injury biomechanics Journal of Biomechanics 60 243 247
- Holbourn , A. 1943 Mechanics of head injuries The Lancet 242 6267 438 441
- Holzapfel , G.A. 2002 Nonlinear solid mechanics: a continuum approach for engineering science Chichester Wiley
- Horgan , T.J. , and Gilchrist , M.D. 2003 The creation of three-dimensional finite element models for simulating head impact biomechanics International Journal of Crashworthiness 8 4 353 366
- Iwamoto , M. , and Nakahira , Y. 2015 Development and Validation of the Total HUman Model for Safety (THUMS) Version 5 Containing Multiple 1D Muscles for Estimating Occupant Motions with Muscle Activation During Side Impacts Stapp Car Crash Journal 59 53 90
- Ji , S. , Ghadyani , H. , Bolander , R.P. , Beckwith , J.G. , Ford , J.C. , McAllister , T.W. , Flashman , L.A. , Paulsen , K.D. , Ernstrom , K. , and Jain , S. 2014 Parametric comparisons of intracranial mechanical responses from three validated finite element models of the human head Annals of Biomedical Engineering 42 1 11 24
- Ji , S. , Zhu , Q. , Dougherty , L. , and Margulies , S.S. 2004 In vivo measurements of human brain displacement Stapp Car Crash Journal 48 227 237
- King , A.I. , Yang , K.H. , Zhang , L. , Hardy , W. , and Viano , D.C. Is head injury caused by linear or angular acceleration Proc. IRCOBI Conference 1 12 Lisbon, Portugal
- Kleiven , S. 2002
- Kleiven , S. 2006 Evaluation of head injury criteria using a finite element model validated against experiments on localized brain motion, intracerebral acceleration, and intracranial pressure International Journal of Crashworthiness 11 1 65 79
- Kleiven , S. 2007 Predictors for traumatic brain injuries evaluated through accident reconstructions Stapp Car Crash Journal 51 81 114
- Kleiven , S. 2013 Why most traumatic brain injuries are not caused by linear acceleration but skull fractures are Frontiers in Bioengineering and Biotechnology 1 1 5
- Kleiven , S. , and Hardy , W.N. 2002 Correlation of an FE model of the human head with local brain motion: Consequences for injury prediction Stapp Car Crash Journal 46 123 144
- Knutsen , A.K. , Magrath , E. , McEntee , J.E. , Xing , F. , Prince , J.L. , Bayly , P.V. , Butman , J.A. , and Pham , D.L. 2014 Improved measurement of brain deformation during mild head acceleration using a novel tagged MRI sequence Journal of Biomechanics 47 14 3475 3481
- Mao , H. , Zhang , L. , Jiang , B. , Genthikatti , V.V. , Jin , X. , Zhu , F. , Makwana , R. , Gill , A. , Jandir , G. , and Singh , A. 2013 Development of a finite element human head model partially validated with thirty five experimental cases Journal of Biomechanical Engineering 135 11 357 366
- Margulies , S.S. , Thibault , L.E. , and Gennarelli , T.A. 1990 Physical model simulations of brain injury in the primate Journal of Biomechanics 23 8 823 836
- Masuzawa , H. , Nadamura , N. , Hirakawa , K. , Sano , K. , and Matsuno , M. 1976 Experimental head injury & concussion in monkey using pure linear acceleration impact Neurologia medico-chirurgica (Tokyo) 16 PT1 77 90
- Mayberry , T. 2008
- Meaney , D. , Smith , D. , Shreiber , D. , Bain , A. , Miller , R. , Ross , D. , and Gennarelli , T. 1995 Biomechanical analysis of experimental diffuse axonal injury Journal of Neurotrauma 12 4 689 694
- Miller , L.E. , Urban , J.E. , and Stitzel , J.D. 2016 Development and validation of an atlas-based finite element brain model Biomechanics and Modeling in Mechanobiology 15 5 1201 1214
- Nahum , A.M. , Smith , R. , and Ward , C.C. Intracranial pressure dynamics during head impact Proc. 21st Stapp Car Crash Conference 337 366 Society of Automotive Engineers Warrendale, PA
- Nusholtz , G.S. , Lux , P. , Kaiker , P. , and Janicki , M.A. Head impact response—Skull deformation and angular accelerations Proc. 28th Stapp Car Crash Conference 41 74 Warrendale, PA
- Ommaya , A. , and Hirsch , A. 1971 Tolerances for cerebral concussion from head impact and whiplash in primates Journal of Biomechanics 4 1 13 21
- Sabet , A.A. , Christoforou , E. , Zatlin , B. , Genin , G.M. , and Bayly , P.V. 2008 Deformation of the human brain induced by mild angular head acceleration Journal of Biomechanics 41 2 307 315
- Stalnaker , R. , Melvin , J. , Nusholtz , G. , Alem , N. , and Benson , J. Head impact response Proc. 21st Stapp Car Crash Conference 303 335 Society of Automotive Engineers Warrendale, PA
- Takhounts , E.G. , Craig , M.J. , Moorhouse , K. , McFadden , J. , and Hasija , V. 2013 Development of Brain Injury Criteria (BrIC) Stapp Car Crash Journal 57 243 266
- Takhounts , E.G. , Ridella , S.A. , Hasija , V. , Tannous , R.E. , Campbell , J.Q. , Malone , D. , Danelson , K. , Stitzel , J. , Rowson , S. , and Duma , S. 2008 Investigation of traumatic brain injuries using the next generation of simulated injury monitor (SIMon) finite element head model Stapp Car Crash Journal 52 1 31
- Trosseille , X. , Tarriere , C. , Lavaste , F. , Guillon , F. , and Domont , A. Development of a FEM of the human head according to a specific test protocol Proc. Proc. 28th Stapp Car Crash Conference 235 253 Society of Automotive Engineers Warrendale, PA
- Unterharnscheidt , F. , and Higgins , L.S. 1969 Pathomorphology of experimental head injury due to rotational acceleration Acta Neuropathologica 12 2 200 204
- VandeVord , P.J. , Leung , L.Y. , Hardy , W. , Mason , M. , Yang , K.H. , and King , A.I. 2008 Up-regulation of reactivity and survival genes in astrocytes after exposure to short duration overpressure Neuroscience Letters 434 3 247 252
- Viano , D.C. , Casson , I.R. , Pellman , E.J. , Zhang , L. , King , A.I. , and Yang , K.H. 2005 Concussion in professional football: brain responses by finite element analysis: part 9 Neurosurgery 57 5 891 916
- von Holst , H. , and Li , X. 2013 Consequences of the dynamic triple peak impact factor in traumatic brain injury as measured with numerical simulation Frontiers in Neurology 4 23
- Zhao , W. , Cai , Y. , Li , Z. , and Ji , S. 2017 Injury prediction and vulnerability assessment using strain and susceptibility measures of the deep white matter Biomechanics and Modeling in Mechanobiology 16 5 1709 1727
- Zhao , W. , Ruan , S. , and Ji , S. 2015 Brain pressure responses in translational head impact: a dimensional analysis and a further computational study Biomechanics and Modeling in Mechanobiology 14 4 753 766
- Zhou , Z. , Li , X. , and Kleiven , S. 2018 Fluid–structure interaction simulation of the brain–skull interface for acute subdural haematoma prediction Biomechanics and Modeling in Mechanobiology 1 19
- Zou , H. , Kleiven , S. , and Schmiedeler , J.P. 2007 The effect of brain mass and moment of inertia on relative brain–skull displacement during low-severity impacts International Journal of Crashworthiness 12 4 341 353
- Zou , H. , Schmiedeler , J.P. , and Hardy , W.N. 2007 Separating brain motion into rigid body displacement and deformation under low-severity impacts Journal of Biomechanics 40 6 1183 1191