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A Reanalysis of Experimental Brain Strain Data: Implication for Finite Element Head Model Validation
Published November 12, 2018 by The Stapp Association in United States
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Relative motion between the brain and skull and brain deformation are biomechanics aspects associated with many types of traumatic brain injury (TBI). Thus far, there is only one experimental endeavor (Hardy et al., 2007) reported brain strain under loading conditions commensurate with levels that were capable of producing injury. Most of the existing finite element (FE) head models are validated against brain-skull relative motion and then used for TBI prediction based on strain metrics. However, the suitability of using a model validated against brain-skull relative motion for strain prediction remains to be determined. To partially address the deficiency of experimental brain deformation data, this study revisits the only existing dynamic experimental brain strain data and updates the original calculations, which reflect incremental strain changes. The brain strain is recomputed by imposing the measured motion of neutral density target (NDT) to the NDT triad model. The revised brain strain and the brain-skull relative motion data are then used to test the hypothesis that an FE head model validated against brain-skull relative motion does not guarantee its accuracy in terms of brain strain prediction. To this end, responses of brain strain and brain-skull relative motion of a previously developed FE head model (Kleiven, 2007) are compared with available experimental data. CORrelation and Analysis (CORA) and Normalized Integral Square Error (NISE) are employed to evaluate model validation performance for both brain strain and brain-skull relative motion. Correlation analyses (Pearson coefficient) are conducted between average cluster peak strain and average cluster peak brain-skull relative motion, and also between brain strain validation scores and brain-skull relative motion validation scores. The results show no significant correlations, neither between experimentally acquired peaks nor between computationally determined validation scores. These findings indicate that a head model validated against brain-skull relative motion may not be sufficient to assure its strain prediction accuracy. It is suggested that a FE head model with intended use for strain prediction should be validated against the experimental brain deformation data and not just the brain-skull relative motion.
- Zhou Zhou - Neuronic Engineering, KTH Royal Institute of Technology, Sto
- Xiaogai Li - Neuronic Engineering, KTH Royal Institute of Technology, Sto
- Svein Kleiven - Neuronic Engineering, KTH Royal Institute of Technology, Sto
- Chirag S. Shah - Humanetics Innovative Solutions, Inc., Farmington Hills, MI,
- Warren N. Hardy - Virginia Tech-Wake Forest Center for Injury Biomechanics, Bl
CitationZhou, Z., Li, X., Kleiven, S., Shah, C. et al., "A Reanalysis of Experimental Brain Strain Data: Implication for Finite Element Head Model Validation," SAE Technical Paper 2018-22-0007, 2018, https://doi.org/10.4271/2018-22-0007.
Data Sets - Support Documents
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