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Development of an Unbiased Validation Protocol to Assess the Biofidelity of Finite Element Head Models used in Prediction of Traumatic Brain Injury
Technical Paper
2016-22-0013
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English
Abstract
This study describes a method to identify laboratory test procedures and impact response requirements suitable for assessing the biofidelity of finite element head models used in prediction of traumatic brain injury. The selection of the experimental data and the response requirements were result of a critical evaluation based on the accuracy, reproducibility and relevance of the available experimental data. A weighted averaging procedure was chosen in order to consider different contributions from the various test conditions and target measurements based on experimental error. According to the quality criteria, 40 experimental cases were selected to be a representative dataset for validation. Based on the evaluation of response curves from four head finite element models, CORA was chosen as a quantitative method to compare the predicted time history response to the measured data. Optimization of the CORA global settings led to the recommendation of performing curve comparison on a fixed time interval of 0-30 ms for intracranial pressure and at least 0-40 ms for brain motion and deformation. The allowable maximum time shift was adjusted depending on the shape of the experimental curves (DMAX = 0.12 for intracranial pressure, DMAX = 0.40 for brain motion and DMAX = 0.25 for brain deformation). Finally, bigger penalization of ratings was assigned to curves with fundamentally incorrect shape compared to those having inaccuracies in amplitude or time shift (cubic vs linear). This rigorous approach is necessary to ensure confidence in the model results and progress in the usage of finite element head models for traumatic brain injury prediction.
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Citation
Giordano, C. and Kleiven, S., "Development of an Unbiased Validation Protocol to Assess the Biofidelity of Finite Element Head Models used in Prediction of Traumatic Brain Injury," SAE Technical Paper 2016-22-0013, 2016, https://doi.org/10.4271/2016-22-0013.Also In
References
- Al-Bsharat , A.S. , Hardy , W.N. , Yang , K.H. , Khalil , T.B. , King , A.I. , and Tashman , S. 1999 Brain/skull relative displacement magnitude due to blunt head impact: New experimental data and model Proc. 43rd Stapp Car Crash Conference 321 332 Society of Automotive Engineers Warrendale PA
- Baeck Katrien 2013 Biomechanical modeling of head impacts - A critical analysis of finite element modeling approaches PhD Thesis KU Leuven
- Bayly P.V. , Cohen T.S. , Leister E.P. , Ajo D. , Leuthard E. , Genin G.M. 2005 Deformation of the human brain induced by mild acceleration J Neurotrauma 22 8 845 856
- Donnelly B.R. , Morgan R.M. , Eppinger R.H. 1983 Durability, repeatability and reproducibility of the NHTSA side impact dummy Proceedings of the 27th Stapp Car Crash Conference SAE Paper No. 831624 299 310
- Faul M.D , Wald M.M. , Xu L. , Coronado V.G. 2010 Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths Center for Disease Control and Prevention, National Center for Injury Prevention and Control Atlanta
- Feng Y. , Abney T.M. , Okamoto R.J. , Pless R.B. , Genin G.M. , Bayly P.V. 2010 Relative brain displacement and deformation during constrained mild frontal head impact J Roy Soc Interface 7 1677 1688
- Gehre C. , Gades H. , Wernicke P. 2009 Objective Rating of Signals Using Test and Simulation Responses Proceedings of the 21st International Technical Conference on the enhanced Safety of Vehicles ESV (Paper 09-0407) Stuttgart (Germany)
- Gennarelli T.A. , Thibault L.E , Graham D.I. 1998 Diffuse Axonal Injury: An Important Form of Traumatic Brain Damage Neuroscientist 4 202 215
- Giordano C. , Cloots R.J.H. , van Dommelen J.A.W , Kleiven S. 2014 The Influence of Anisotropy on Brain Injury Prediction J. Biomech 47 1052 1059
- Giordano C. , Kleiven S. 2014 Evaluation of Axonal Strain as a Predictor for Mild Traumatic Brain Injuries Using Finite Element Modeling Stapp Car Crash Journal 58 29 61
- Hardy , W.N. , Foster , C.D. , Mason , M.J. , Yang , K.H. , King , A.I. , and Tashman , S. 2001 Investigation of Head Injury Mechanisms Using Neutral Density Technology and High- Speed Biplanar X-ray Stapp Car Crash Journal 45 337 368
- Hardy W.N. , Mason M. , Foster C.D. , Yang K.H. , King A.I. 2006 W.N. Comparison of intracranial pressure response to cadaver head kinematics J Biomech 39 S155
- Hardy W.N. , Mason M.J. , Foster C.D. , Shah C.S. , Kopacz J.M. , Yang K.H. , King A.I. , Bishop J. , Bey M. , Anderst W. , Tashman S. 2007 A Study of the Response of the Human Cadaver Head to Impact Stapp Car Crash Journal 51 2007
- Holbourn A.H. 1943 Mechanics of head injuries Lancet 2 438 441
- ISO/TR 9790 1999 Road vehicles -- Anthropomorphic side impact dummy -- Lateral impact response requirements to assess the biofidelity of the dummy
- Iwamoto M. , Nakahira Y. 2015 Development and Validation of the Total HUman Model for Safety (THUMS) Version 5 Containing Multiple 1D Muscles for Estimating Occupant Motions with Muscle Activation During Side Impacts Stapp Car Crash Journal 59 53 90
- Ji S. , Ghadyani H. , Bolander R.P. , Beckwith J.G. , Ford J.C. , McAllister T.W. , Flashman L.A. , Paulsen K.D. , Ernstrom K. , Jain S. , Raman R. , Zhang L. and Greenwald R.M. 2014 Parametric Comparisons of Intracranial Mechanical Responses from Three Validated Finite Element Models of the Human Head Annals of Biomedical Engineering 42 1 11 24
- Kimpara H. , Nakahira Y. , Iwamoto M. , Miki K. , Ichihara K. , Kawano S. , Taguchi T. 2006 Investigation of anteroposterior head-neck responses during severe frontal impacts using a brain-spinal cord complex FE model Stapp Car Crash J 50 509 544
- Kleiven S. 2002 Finite Element Modeling of the Human Head (Doctoral thesis) Technical Report 2002-9 Department of Aeronautics, Kungliga Tekniska Högskolan Stockholm 0280-4646
- Kleiven S. 2006 Evaluation of head injury criteria using an FE model validated against experiments on localized brain motion, intra-cerebral acceleration and intra-cranial pressure Int. J. Crashworthiness 11 65 79
- Kleiven S. 2007 Predictors for traumatic brain injuries evaluated through accident reconstructions Stapp Car Crash J 51 81 114
- Kleiven S. , Hardy W.H. 2002 Correlation of an FE model of the human head with experiments on localized motion of the brain - consequences for injury prediction Stapp Car Crash J. 46 123 144
- Langlois J.A. , Rutland-Brown W. , Wald M.M. 2006 The Epidemiology and Impact of Traumatic Brain Injury - A Brief Overview J Head Trauma Rehabil 21 5 375 378
- Mao H. , Zhang L. , Jiang B. , Genthikatti V.V. , Jin X. , Zhu F. , Makwana R. , Gill A. , Jandir G. , Singh A. , Yang K.H. 2013 Development of a finite element human head model partially validated with thirty five experimental cases J Biomech Eng. 135 11 111002 10.1115/1.4025101
- Miller L.E. , Urban J.E. , Stitzel J.D. 2016 Development and validation of an atlas-based finite element brain model Biomech Model Mechanobiol 15 5 1201 1214
- Nahum A.M. , Smith R. , Ward C.C. 1977 Intracranial Pressure Dynamics During Head Impact Proc. 21st Stapp Car Crash Conference 337 366 Society of Automotive Engineers Warrendale, PA
- O'Connor W.T. , Smyth A. , Gilchrist M.D. 2011 Animal models of traumatic brain injury: A critical evaluation Pharmacology & Therapeutics 130 2 106 113
- Otte D. , Jänscha M. , Haasperb C. 2012 Injury protection and accident causation parameters for vulnerable road users based on German In-Depth Accident Study GIDAS Accident Analysis & Prevention 44 1 149 153
- Shaw N.A. 2002 The neurophysiology of concussion Progress in Neurobiology 67 281 344
- Tagliaferri F. , Compagnone C. , Korsic M. , Servadei F. , Kraus J. 2006 A systematic review of brain injury epidemiology in Europe Acta Neurochir 148 3 255 268
- Trosseille , X. , Tarriere , C. , Lavaste , F. , Guillon F. , and Domont , A. 1992 Development of a F.E.M. of the human head according to a specific test protocol Proc. 36th Stapp Car Crash Conference 235 253 Society of Automotive Engineers Warrendale, PA
- VandeVord P.J. , Leung L.Y. , Hardy W. , Masona M. , Yang K.H. , King A.I. 2008 Up-regulation of reactivity and survival genes in astrocytes after exposure to short duration overpressure Neuroscience Letters 434 247 252