While initial Connected Vehicle research in the United States was focusing almost exclusively on passenger vehicles, a program was envisioned that would enhance highway safety, mobility, and operational efficiencies through the application of the technology to commercial vehicles. This program was realized in 2009 by funding from the I-95 Corridor Coalition, led by the New York State Department of Transportation, and called the Commercial Vehicle Infrastructure Integration (CVII) program. The CVII program focuses on developing, testing and deploying Connected Vehicle technology for heavy vehicles. Since its inception, the CVII program has developed numerous Vehicle-to-Vehicle and Vehicle-to-Infrastructure applications for trucks that leverage communication with roadside infrastructure and other light and heavy duty vehicles to meet the objectives of the program. This program was a springboard for other Connected Commercial Vehicle programs in the US that have been conducted, or are currently being conducted, by USDOT, State DOTs, and commercial OEMs. This paper will highlight the efforts performed and lessons learned under the CVII program and the relationship to other Connected Commercial Vehicle programs that have been conducted and are currently being conducted in the US.