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Predictors for Traumatic Brain Injuries Evaluated through Accident Reconstructions
Technical Paper
2007-22-0003
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English
Abstract
The aim of this study is to evaluate all the 58 available NFL cases and compare various predictors for mild traumatic brain injuries using a detailed and extensively validated finite element model of the human head. Global injury measures such as magnitude in angular and translational acceleration, change in angular velocity, head impact power (HIP) and HIC were also investigated with regard to their ability to predict the intracranial pressure and strains associated with injury. The brain material properties were modeled using a hyperelastic and viscoelastic constitutive law. Also, three different stiffness parameters, encompassing a range of published brain tissue properties, were tested. 8 tissue injury predictors were evaluated for 6 different regions, covering the entire cerebrum, as well as for the whole brain. In addition, 10 head kinematics based predictors were evaluated both for correlation with injury as well as with strain and pressure. When evaluating the results, a statistical correlation between strain, strain rate, product of strain and strain rate, Cumulative Strain Damage Measure (CSDM), strain energy density, maximum pressure, magnitude of minimum pressure, as well as von Mises effective stress, with injury was found when looking into specific regions of the brain. However, the maximal pressure in the gray matter showed a higher correlation with injury than other evaluated measures. On the other hand, it was possible, through the reconstruction of a motocross accident, to re-create the injury pattern in the brain of the injured rider using maximal principal strain. It was also found that a simple linear combination of peak change in rotational velocity and HIC showed a high correlation (R=0.98) with the maximum principal strain in the brain, in addition to being a significant predictor of injury. When applying the rotational and translational kinematics separately for one of the cases, it was found that the translational kinematics contribute very little to the intracranial distortional strains while the rotational kinematics contributes insignificantly to the pressure response. This study underlines that the strain based brain tissue injury predictors are very sensitive to the choice of stiffness for the brain tissue.
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Citation
Kleiven, S., "Predictors for Traumatic Brain Injuries Evaluated through Accident Reconstructions," SAE Technical Paper 2007-22-0003, 2007, https://doi.org/10.4271/2007-22-0003.Also In
References
- Adams JH Doyle D Ford I Gennarelli TA Graham DI McLellan DR. 1989 Diffuse axonal injury in head injury definition, diagnosis and grading. Histopathology 15 1 49 59
- Anderson R.W.G. Brown C.J. Blumbergs P.C. Scott G. Finney J.W. Jones N.R. McLean A.J. 1999 Mechanics of axonal injury An experimental and numerical study of a sheep model of head impact, Proc. 1999 IRCOBI Conf. Sitges Spain 107 120
- Anzelius A. 1943 The effect of an impact on a spherical liquid mass. Acta. Pathol. Microbiol. Scand., Suppl 48 153 159
- Arbogast K.B. Prange M.T. Meaney D.F. Margulies S.S. 1997 Properties of Cerebral Gray and White Matter Undergoing Large Deformation. Prevention Through Biomechanics, Symposium Proceedings Wayne State University 33 39
- Arbogast K.B. Margulies S.S. 1997 Regional differences in mechanical properties of the porcine central nervous system, Proc. 41 st Stapp Car Crash Conference SAE Paper No. 973336 , Society of Automotive Engineers Warrendale, PA
- Bandak F.A. Eppinger R.H. 1994 A three-dimensional FE analysis of the human brain under combined rotational and translational accelerations, Proc. 38 th Stapp Car Crash Conference 145 163 Society of Automotive Engineers Warrendale, PA
- Bain B.C. Billiar K.L. Shreiber D.I. McIntosh T.K. Meaney D.F. 1996 In vivo mechanical thresholds for traumatic axonal damage. Proc. of AGARD AMP Specialists’ Meeting, Mescalero New mexico, USA 7 9 November 1996
- Bain A.C. Meaney D.F. 2000 Tissue-Level Thresholds for Axonal Damage in an Experimental Model of Central Nervous System White Matter Injury. Journal of Biomechanical Engineering 16 615 622
- Barkataki I. Kumari V. Das M. Taylor P. Sharma T. 2006 Volumetric structural brain abnormalities in men with schizophrenia or antisocial personality disorder. Behavioural Brain Research 169 239 247
- Bellora A Krauss R Van Poolen L. 2001 Meeting Interior Head Impact Requirements: A Basic Scientific Approach Society of Automotive Engineers, Paper No. 2001-01-0469
- Bland M. 2000 An introduction to medical statistics third edition Oxford university press Oxford, UK
- Blatter D.D. Bigler E.D. Gale S.D. Johnson S.C. Anderson C.V. Burnett B.M. Parker N. Kurth S. Horn S.D. 1995 Quantitative Volumetric Analysis of Brain MR: Normative Database Spanning 5 Decades of Life. American J. Neurorad 16 2 241 251
- Bradshaw D.R.S. Morfey C.L. 2001 Pressure and shear response in brain injury models. Proceedings of the 17 th Int. Technical Conferance on the Enhanced Safety of Vehicles Amsterdam, The Netherlands
- Cater HL Sundstrom LE Morrison B III 2005 Temporal development of hippocampal cell death is dependent on tissue strain but not strain rate. J.Biomechanics (in press)
- Claessens M. Sauren F. Wismans J. 1997 Modeling of the Human Head Under Impact Conditions A Parametric Study. Proc. 41 st Stapp Car Crash Conference, SAE Paper No. 973338 315 328 Society of Automotive Engineers Warrendale, PA
- DiMasi F. Eppinger R.H. Bandak F.A. 1995 Computational analysis of head impact response under car crash loadings, Proc 39th Stapp Car Crash Conf
- Donnelly B.R. 1998 Brain tissue material properties: A comparison of results. Biomechanical research: Experimental and computational, Proc. Of the 26 th int. Workshop 47 57
- Fearon P. O'Connell P. Frangou S. Aquino P. Nosarti C. Allin M. Taylor M. Stewart A. Rifkin L. Murray R. 2002 Brain Volumes in Adult Survivors of Very Low Birth Weight A Sibling-Controlled Study. Pediatrics 114 367 371
- Franceschini G. 2006 The mechanics of human brain tissue, PhD-thesis University of Trento Italy
- Franceschini G. Bigoni D. Regitnig P. Holzapfel G.A. 2006 Brain tissue deforms similarly to filled elastomers and follows consolidation theory. J Mechanics and Physics of Solids 54 12 2592 2620
- Galbraith J.A. Thibault L.E. Matteson D.R. 1993 Mechanical and electrical responses of the squid giant axon to simple elongation. J. Biomech. Engng 115 13 22
- Gazzaniga M.S. Ivry R.B. Mangun G.R. 1998 Cognitive Neuroscience - The biology of the mind W.W. Norton & Company Inc New York
- Gefen A. Margulies S.S. 2004 Are in vivo and in situ brain tissues mechanically similar? Journal of Biomechanics 37 1339 1352
- Gennarelli T.A. Thibault L.E. Adams J.H. Graham D.I. Thompson C.J. Marcincin R.P. 1982 Diffuse Axonal Injury and Traumatic Coma in the Primate. Ann. Neurol 12 564 574
- Gennarelli T.A. Thibault L.E. Tomei G. Wiser R. Graham D.I. Adams J. 1987 Directional dependence of axonal brain injury due to centroidal and non-centroidal acceleration SAE Paper No. 872197 49 53 Proc. 31 st Stapp Car Crash Conference Society of Automotive Engineers Warrendale, PA
- Graff K.F. 1975 Wave motion in elastic solids Dover Publ. Inc New York
- Gurdjian ES Lissner HR. Mechanisms of head injury as studied by the cathode ray oscilloscope: preliminary report. J Neurol Neurosurg Psychiatry 1944 393 399
- Hardan AY Minshew NJ Harenski K Keshavan MS. 2001 Posterior fossa magnetic resonance imaging in autism. J Am Acad Child Adolesc Psychiatry 40 6 666 72
- Hardy WN Khalil TB King AI. Litterature review of head injury biomechanics. Int J Impact Engng 1994 15 4 561 568
- Hardy W.N. Foster C. Mason M. Yang K. King A. Tashman S. 2001 Investigation of Head Injury Mechanisms Using Neutral Density Technology and High-Speed Biplanar X-ray. 45 th Stapp Car Crash Journal 337 368 The Stapp Association Ann Arbor, MI
- Ho J. Kleiven S. 2006 An automatic method to generate a patient specific finite element head model, Proc. 5th World Congress of Biomechanics, München Germany Journal of Biomechanics 2006 39
- Ho J. Kleiven S. 2007 Dynamic response of the brain with vasculature: A three-dimensional computational study Journal of Biomechanics, doi:10.1016/j.jbiomech.2007.02.011
- Ho J. von Holst H. Kleiven S. 2007 Automatic generation of patient specific finite element head models from MR T1-weighted images Submitted to Medical Engineering and Physics
- Hodgson V.R. Thomas L.M. Khalil T.B. 1983 The Role of Impact Location in Reversible Cerebral Concussion SAE Paper No. 831618 , Proc. 27th Stapp Car Crash Conf., Society of Automotive Engineers 225 240
- Holbourn A.H.S. 1943 Mechanics of head injury. Lancet 2 October 9 438 441
- Horgan T.J. Gilchrist M.D. 2003 The creation of three-dimensional finite element models for simulating head impact biomechanics International Journal of Crashworthiness 8 3 1 14
- King A.I. Yang K.H. Zhang L. Hardy W.N. Viano D.C. 2003 Is head injury caused by linear or angular acceleration? Proc. IRCOBI Conf Lisbon (Portugal)
- Kleiven S. 2002 Finite Element Modeling of the Human Head. Doctoral Thesis. Technical Report 2002-9 Department of Aeronautics Royal Institute of Technology Stockholm, Sweden
- Kleiven S. Hardy W.N. 2002 Correlation of an FE model of the Human Head with Experiments on localized Motion of the Brain - Consequences for Injury Prediction. 46 th Stapp Car Crash Journal 123 144
- Kleiven S. von Holst H. 2002 Consequences of Head Size following Trauma to the Human Head. J. Biomechanics 35 2 153 160
- Kleiven S. Peloso P.M. von Holst H. 2003 The Epidemiology of Head Injuries in Sweden from 1987 to 2000 Journal of Injury Control and Safety Promotion 10 1
- Kleiven S. 2003 Influence of Impact Direction to the Human Head in Prediction of Subdural Hematoma Journal of Neurotrauma 20 4 365 379
- Kleiven S. Evaluation of head injury criteria using an FE model validated against experiments on localized brain motion, intra-cerebral acceleration, and intra-cranial pressure International Journal of Crashworthiness 11 1 65 79
- Kleiven S. Biomechanics as a forensic science tool - Reconstruction of a traumatic head injury using the finite element method Scand J Forens Sci 2 73 78
- Kleiven S. Biomechanical reconstruction of traumatic brain injuries - Correlation between injury patterns and FE models, Proc. 5th World Congress of Biomechanics München, Germany Journal of Biomechanics 2006 39
- Kleiven S. von Holst H. 2007 Biomechanical reconstruction of real-world traumatic brain injuries Correlation between injury pattern and an FE model, Manuscript
- Lee M.C. Haut R.C. 1989 Insensitivity of tensile failure properties of human bridging veins to strain rate Implications in biomechanics of subdural hematoma. J. Biomech. 22 (6/7) 537 542
- Lewine JD Davis JT Bigler ED Thoma R Hill D Funke M Sloan JH Hall S Orrison WW. 2007 Objective documentation of traumatic brain injury subsequent to mild head trauma: multimodal brain imaging with MEG, SPECT, and MRI. J Head Trauma Rehabil 22 3 141 55
- Livermore Software Technology Corporation 2001 “LS-Dyna Keyword User's Manual, Version 960” and “LS-Dyna Theory Manual” Livermore, CA, U.S.A
- Lövenhielm P. 1974 Strain tolerance of the Vv. Cerebri Sup. (bridging veins) calculated from head-on collision tests with cadavers. Z. Rechtsmedizin 75 2 131 144
- Lübock P. Goldsmith W. 1980 Experimental cavitation studies in a model head-neck system. Journal of Biomechanics 13 1041 1052
- Margulies S.S. Thibault L.E. 1992 A Proposed Tolerance Criterion for Diffuse Axonal Injury in Man. J. Biomech 25 8 917 923
- MathWorks Inc 1994 MathWorks, MATLAB Reference Guide
- McCracken P.J. Manduca A. Felmlee J. Ehman R.L. 2005 Mechanical Transient-Based Magnetic Resonance Elastography, Magnetic Resonance in Medicine 53 628 639
- McElhaney J.H. Roberts V.L. Hilyard J.F. 1976 Properties of human tissues and components nervous tissues, in Handbook of human tolerance Automobile Research Institute Inc Tokyo, Japan 143
- Melvin J.W. Lighthall J.W. Ueno K. 1993 Brain Injury Biomechanics, in Accidental Injury Nahum A.M. Melvin J.W. New York 269 290
- Miller R.T. Margulies S.S. Leoni M. Nonaka M. Chen X. Smith D.H. Meaney D.F. 1998 Finite Element Modeling Approaches for Predicting Injury in an Experimental Model of Severe Diffuse Axonal Injury. Proc. 42 nd Stapp Car Crash Conference SAE Paper No. 983154 155 166 Society of Automotive Engineers Warrendale, PA
- Monson 2003 Axial mechanical properties of fresh human cerebral blood vessels. J Biomech Eng 2003 Apr 125 2 288 94
- Morrison B. III Cater H.L. Wang C.C.B. Thomas F.C. Hung C.T. Ateshian G.A. Sundström L.E. 2003 A tissue level tolerance criterion for living brain developed in an in vitro model of traumatic mechanical loading. 47th Stapp Car Crash Journal SAE Paper No. 2003-22-0006
- Newman J.A. Shewchenko N. Welbourne E. 2000 A Proposed New Biomechanical Head Injury Assessment Function - The Maximum Power Index, Proc. 44th Stapp Car Crash Conf SAE Paper No. 2000-01-SC16
- Newman J.A. Beusenberg M.C. Shewchenko N. Withnall C. Fournier E. 2005 Verification of biomechanical methods employed in a comprehensive study of mild traumatic brain injury and the effectiveness of American football helmets
- Nicolle S. Lounis M. Willinger R. Palierne J.F. 2005 Shear linear behavior of brain tissue over a large frequency range. Biorheology 42 3 209 23
- Ogden R.W. 1984 Non-Linear Elastic Deformations Dover Publications, Inc Mineola, New York
- Peduzzi P. Concato J. Kemper E. Holford T.R. Feinstein A.R. 1996 A simulation study of the number of events per variable in logistic regression analysis. Journal of Clinical Epidemiology 49 1373 9
- Pellman EJ Viano DC Tucker AM Casson IR Waeckerle JF 2003 Concussion in professional football: Location and direction of helmet impacts-Part 2. Neurosurgery 53 1328 1341
- Pellman EJ Powell JW Viano DC Casson IR Tucker AM Feuer H Lovell M Waeckerle JF Robertson DW. 2004 Concussion in professional football: epidemiological features of game injuries and review of the literature-part 3. Neurosurgery 54 1 81 96
- Pellman E.J. Viano DC Tucker AM Casson IR Arfken C Feuer H. 2005 Concussion in professional football: Players returning to the same game - Part 7. Neurosurgery 56 79 92
- Prange M.T. Meaney D.F. Margulies S.S. 2000 Defining Brain Mechanical Properties Effects of Region, Direction, and Species. Proc. 44 th Stapp Car Crash Journal, Paper No. 2000-01-SC15 The Stapp Association Ann Arbor, MI
- Puso MA Weiss JA. 1998 Finite element implementation of anisotropic quasi-linear viscoelasticity using a discrete spectrum approximation. J Biomech Eng 1998 Feb 120 1 62 70
- Ruan J.S. Khalil T.B. King A.I. 1997 Impact Head Injury Analysis Using an Explicit Finite Element Human Head Model Journal of Traffic Medicine 25 33 40
- 2006 SPSS 14.0 reference guide SPSS Inc Chicago, Illinois
- Stalnaker R.L. 1969 Mechanical properties of the head, Ph.D. dissertation West Virginia University
- Shreiber D.I. Bain A.C. Meaney D.F. 1997 In vivo thresholds for mechanical injury to the blood-brain barrier SAE Paper No. 973335 , in: 41st Stapp Car Crash Conf., Society of Automotive Engineers 177 190
- Takhounts E.G. Eppinger R.H. Campbell J.Q. Tannous R.E. Power E.D. Shook L.S. 2003 On the development of the SIMon Finite Element Head Model, 47th Stapp Car Crash Journal
- Thibault L.E. Gennarelli T.A. Margulies S.S. Marcus J. Eppinger R. 1990 The strain dependent pathophysiological consequences of inertial loading on central nervous system tissue, Proc. IRCOBI Conf., Bron Lyon, France 191 202
- Thibault L.E. 1993 Brain injury from the macro to the micro level and back again What have we learned to date? Proc. IRCOBI Conf Eindhoven, The Netherlands 3 25
- Thomas L.M. Roberts V.L. Gurdijan E.S. 1967 Impact-induced pressure gradients along three orthogonal axes in the human skull Journal of Neurosurgery 26 316 349
- Ueno K. Melvin J.W. 1995 Finite element model study of head impact based on hybrid III head acceleration The effects of rotational and translational acceleration. J. Biomechanical Engineering 117 3 319 328
- Ungerleider L.G. Mishkin M. 1982 Two cortical visual systems, In Engle D.J. Goodale M.A. Mansfield R.J. Analysis of visual behaviour MIT press Cambridge, MA 549 586
- Viano DC Casson IR Pellman E.J. Zhang L. King A.I. Yang K.H. 2005 Concussion in professional football Brain responses by finite element analysis- Part 9.Neurosurgery 57 5 891 916
- Viano D.C. Lövsund P. 1999 Biomechanics of brain and spinal-cord injury analysis of neuropathologic and neurophysiologic experiments. J. Crash Prevention and Injury Control 1 35 43
- Willinger R. Baumgartner D. 2003 Human head tolerance limits to specific injury mechanisms, Int J Crashworthiness 8 6 605 617
- Willinger R. Taled L. Pradore P. 1995 Head biomechanics: from the finite element model to the physical model. Proc. IRCOBI Conference 245 260 Switzerland International Research Council on the Biomechanics of Impact, Bron France
- Zhang L. Yang K.H. King A.I. 2001 Comparison of Brain Responses Between Frontal and Lateral Impacts by Finite Element Modeling. Journal of Neurotrauma 18 1 21 30
- Zhang L. Yang K.H. King A.I. 2004 “A Proposed Injury Threshold for Mild Traumatic Brain Injury.” J. Biomechanical Engineering 126 1 226 236
- Zhou C. Khalil T.B. King A.I. 1995 A new model comparing impact responses of the homogeneous and inhomogeneous human brain. Proc. 39 th Stapp Car Crash Conference 121 137 Society of Automotive Engineers Warrendale, PA