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Microwave Powered Gravitationally Independent Medical Grade Water Generation
Technical Paper
2007-01-3176
ISSN: 0148-7191, e-ISSN: 2688-3627
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English
Abstract
The on-demand production of Medical Grade Water (MGW) is a critical biomedical requirement for future long-duration exploration missions. Potentially, large volumes of MGW may be needed to treat burn victims, with lesser amounts required to reconstitute pharmacological agents for medical preparations and biological experiments, and to formulate parenteral fluids during medical treatment. Storage of MGW is an untenable means to meet this requirement, as are nominal MGW production methods, which use a complex set of processes to remove chemical contaminants, inactivate all microorganisms, and eliminate endotoxins, a toxin originating from gram-negative bacteria cell walls. An innovative microgravity compatible alternative, using a microwave-based MGW generator, is described in this paper. The MGW generator efficiently couples microwaves to a single-phase flowing stream, resulting in super-autoclave temperatures. Equivalent microbial lethality is achieved much faster, and of equal significance, endotoxins are inactivated, eliminating the need for expendable ultrafiltration membranes, which are normally used for this purpose.
Authors
Citation
Akse, J., Zavala, D., Wheeler, R., Dahl, R. et al., "Microwave Powered Gravitationally Independent Medical Grade Water Generation," SAE Technical Paper 2007-01-3176, 2007, https://doi.org/10.4271/2007-01-3176.Also In
References
- Block, S.S. Disinfection, Sterilization, and Preservation 3rd Lea & Febiger 1987
- Thuery, J. Microwaves: Industrial, Scientific and Medical Applications Artech House 1992
- von Hippel, A. Dielectrics and Waves Wiley New York 1954
- von Hippel, A. Dielectric Materials and Applications Technology Press of MIT Cambridge 1954
- Bykov, Y.V. Rybakov, K.I. Semenov, V.E. High-Temperature Microwave Processing of Materials J. Phys. D: Appl. Phys. 34 R55 R75 2001
- Haala, J. Wiesbeck, W. Modeling Microwave and Hybrid Heating Processes Including Heat Radiation Effects IEEE Trans. Microwave Theory Technol. 50 1346 1354 2002
- Basak, T. Ayappa, K.G. Influence of Internal Convection during Microwave Thawing of Cylinders AIChE J. 47 835 850 2001
- Alpert, Y. Jerby, E. Coupled Thermal Electromagnetic Model for Microwave Heating of Temperature-Dependent Dielectric Media IEEE Trans. Plasma Sci. 27 555 562 1999
- Vriezinga, C.A. Thermal Runaway in Microwave Heated Isothermal Slabs, Cylinders, and Spheres J. Appl. Phys. 83 438 442 1998
- Torres, F. Jecko, B. Complete FDTD Analysis of Microwave Heating Processes in Frequency Dependent and Temperature-Dependent Media IEEE Trans. Microwave Theory Technol. 45 108 117 1997
- Adu, B. Otten, L. Afenya, E. Groenevelt, P. Thermodynamics of Microwave (Polarized) Heating Systems J. Microwave Power Electromag. Energy 30 90 96 1995
- Barringer, S.A. Davis, E.A. Gordon, J. Ayappa, K.G. Davis, H.T. Effect of Sample Size on the Microwave Heating Rate: Oil vs. Water AIChE J. 40 1433 1439 1994
- Atwater, J.E. Wheeler, R.R., Jr. A Complex Permittivity Study of Sorbent Materials and Volatile Contaminants 1 Final Report, NASA Contract NAS2-97017 June 1999
- Atwater, J.E. Wheeler, R.R., Jr. Complex Permittivities and Dielectric Relaxation of Granular Activated Carbons at Microwave Frequencies between 0.2 and 26 GHz Carbon 41 9 1801 1807 2003
- Atwater, J.E. Wheeler, R.R., Jr. Temperature Dependent Complex Permittivities of Graphitized Carbon Blacks at Microwave Frequencies Between 0.2 and 26 GHz J. Mater. Sci. 39 151 157 2004
- Atwater, J.E. Wheeler, R.R., Jr. Microwave Permittivity and Dielectric Relaxation of a High Surface Area Activated Carbon Appl. Phys. A 79 125 129 2004
- Reitschel, E.T. Brade, H. Brade, L. Brandenburg, K. Schade, U. Seydel, U. Zahringer, U. Galanos, C. Luderitz, O. Westphal, O. Labischinski, H. Kusumoto, S. Shiba, T. Lipid A, the endotoxic center of bacterial lipopolysaccharides: Relation of chemical structure to biological activity Detection of bacterial endotoxins with Limulus amebocyte lysate test Watson, S.W. Levin, J. Novitsky, T.J. Alan R. Liss New York 1987
- van Putten, J.P.M. Grassme, U.C. Robertson, B.D. Schwan, E.T. Function of lipopolysaccharide in the invasion of Neisseris gonorrhoeae into human mucosal cells 49 58 Progress in Clinical and Biological Research 392 Bacterial Endotoxins: Lipopolysaccharides from Genes to Therapy Levin, J. Alving, C.R. Munford, R.S. Redl, H. John Wiley & Sons New York 1994
- Bahrami, S. Schlag, G. Yao, Y-M. Redl, H. Significance of translocation/endotoxin in the development of systemic sepsis following trauma and/or hemorrhage 69 78 Progress in Clinical and Biological Research 392 Bacterial Endotoxins: Lipopolysaccharides from Genes to Therapy Levin, J. Alving, C.R. Munford, R.S. Redl, H. John Wiley & Sons New York 1994
- Darveau, R.P. Cunningham, M.D. Seachord, R.C.P. Aruffo, A. The ability of bacteria associated with chronic inflammatory disease to stimulate E-selectin expression and neutrophil adhesion 69 78 Progress in Clinical and Biological Research 392 Bacterial Endotoxins: Lipopolysaccharides from Genes to Therapy Levin, J. Alving, C.R. Munford, R.S. Redl, H. John Wiley & Sons New York 1994
- Takayama, K. Din, Z.Z. Mukerjee, P. Physical state of biologically active lipopolysaccharide 183 193 Progress in Clinical and Biological Research 392 Bacterial Endotoxins: Lipopolysaccharides from Genes to Therapy Levin, J. Alving, C.R. Munford, R.S. Redl, H. John Wiley & Sons New York 1994
- Marcus, S. Anselmo, C. Perkins, J.J. Studies on bacterial pyrogenicity. I. Quantitative basis Proc. Soc. Exp. Biol. Med. 99 359 1958
- Zahringer, U. Knirel, Y.A. Lindner, B. Helbig, J.H. Sonesson, A. Marre, R. Reitschel, E.T. The lipopolysaccharide of Legionella pneumophila serogroup 1 (strain Philadelphia 1): Chemical Structure and Biological Significance 113 139 Progress in Clinical and Biological Research 392 Bacterial Endotoxins: Lipopolysaccharides from Genes to Therapy Levin, J. Alving, C.R. Munford, R.S. Redl, H. John Wiley & Sons New York 1994
- Novitsky, T.J. Dawson, M.E. Colentro, W.V. A new approach for monitoring bacteria: the kinetic LAL assay Ultrapure Water November 1985
- United States Pharmacopeia and National Formulary United States Pharmacopeial Convention Rockville, Md. 1347 1352 1999
- Pearson, F.C. III Pyrogens: Endotoxins, LAL Testing, and Depyrogenation 30 35 in Advances in Parenteral Sciences Robinson, J.R. Marcel Dekker, Inc. New York 1985
- Fujii, S Takai, M. Maki, T. Wet Heat Inactivation of Lipopolysaccharide From E coli Serotype 055:B5 PDA J. Pharm. Sci. Tech. 56 220 227 2002
- Bamba, T Matsui R Watabe K. Effect of Steam-Heat Treatment With/Without Divalent Cations On the Inactivation of Lipopolysaccharides From Several Bacterial Species PDA J. Pharm. Sci. Tech. 50 129 135 1996
- Methods for Developing Spacecraft Water Exposure Guidelines Subcommittee on Spacecraft Water Exposure Guidelines, Committee on Toxicology, Board on Environmental Studies and Toxicology National Research Council, The National Academies Press 2000 http://www.nap.edu/catalog/9892.html#orgs
- Carter, L. Tabb, D. Tatara, J.D. Mason, R.K. Performance Qualification Test of the ISS Water Processor Assembly (WPA) Expendables SAE Technical Paper Series 2005-01-2837 35th International Conference on Environmental Systems Rome 2005