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Bioluminescent Bioreporter Integrated Circuits (BBICs): Whole-Cell Environmental Monitoring Devices
Technical Paper
2000-01-2420
ISSN: 0148-7191, e-ISSN: 2688-3627
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English
Abstract
We report a chemical sensing technology composed of engineered bioluminescent bacteria placed on an integrated microluminometer. The bacteria have been engineered to luminesce when the targeted compound is metabolized, while the microluminometer detects, processes, and then reports the magnitude of this optical signal. In this work we report our progress in the development of these biosensors and present data from our prototypes.
Authors
- Michael L. Simpson - Oak Ridge National Laboratory
- Michael J. Paulus - Oak Ridge National Laboratory
- Gerald E. Jellison - Oak Ridge National Laboratory
- Gary S. Sayler - University of Tennessee Center for Environmental Biotechnology
- David E. Nivens - University of Tennessee Center for Environmental Biotechnology
- Hebe M. Dionisi - University of Tennessee Center for Environmental Biotechnology
- Steven Ripp - University of Tennessee Center for Environmental Biotechnology
- Bruce M. Applegate - University of Tennessee Center for Environmental Biotechnology
- Greg Patterson - University of Tennessee Dept. of Electrical and Computer Eng.
- Eric Bolton - University of Tennessee Dept. of Electrical and Computer Eng.
- Chris Arnott - University of Tennessee Dept. of Electrical and Computer Eng.
- James Rochelle - University of Tennessee Dept. of Electrical and Computer Eng.
Citation
Simpson, M., Paulus, M., Jellison, G., Sayler, G. et al., "Bioluminescent Bioreporter Integrated Circuits (BBICs): Whole-Cell Environmental Monitoring Devices," SAE Technical Paper 2000-01-2420, 2000, https://doi.org/10.4271/2000-01-2420.Also In
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