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Has Medication with Benzodiazepines a Beneficial or Detrimental Effect on Car Drivers, or is Alcohol Still the Villain?
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Abstract
There are groups in the community who claim that road safety can be improved if patients who receive benzodiazepine tranquilizers are prevented from driving a car. These groups disregard the fact that there exists no study to show that these drugs are a causal factor in crashes. This paper will mainly review the effect of diazepam which is one of the older compounds. Some studies have shown that performance on psychomotor skill tests are at times affected by diazepam medication. A few of these studies report a decrement in performance, some an improvement, but the results of the vast majority of studies tend to be inconclusive. If detrimental effects occur they usually manifest themselves during the early stages of medication and when high doses are given. Many published studies suffer from methodological errors; there is little evidence that the tests used by the different teams measure the same aspect of behavior. The epidemiological approach has failed to supply the information needed to adequately describe the relationship between all drugs and road safety. Large scale field studies have not been attempted with any pharmaceutical drug. It is difficult to estimate the use of tranquilizers amongst the driving population and to ascertain whether it is similar to that of the general population. Women of middle-age are overrepresented amongst diazepam users and young men are more likely to be involved in a crash.
Citation
Landauer, A., "Has Medication with Benzodiazepines a Beneficial or Detrimental Effect on Car Drivers, or is Alcohol Still the Villain?," SAE Technical Paper 860045, 1986, https://doi.org/10.4271/860045.Also In
References
- Wittels, P.Y. Stonier, P.D. The effects of benzodiazepines on psychomotor performance in patients In Hindmarch, I. Stonier, P.D. Clobazam London Royal Society of Medicine 1981
- Benjamin, F.B. Areview of the safety hazards due to poor health, drugs, and their interaction Human Factors 1977 19 127 137
- Nicholson A.N. Performance and impaired performance British Journal of Clinical Pharmacology 1976 3 521 522
- Legg, N.J. Malpas, A. Scott, D.F. Effectsof tranquillizers and hypnotics on driving British Medical Journal 1973 1 417
- Soehring, K. Wolters, H.G. PharmakologischeGrundlagen der Wirkung von Arznei-mitteln auf die Verkehrstüchtigkeit In Wagner, K. Wagner H.-J. Hand-buch der Verkehrsmedizin Berlin. Heidelberg, New York Springer 1968
- Greenblatt, D.J. Divoll, M. Abemethy, D. R. Ochs, H.R. Shader, R.I. Clinicalpharmacokinetics of the newer benzodiazepines Clinical Pharmacokinetics 1983 8 233 252
- Bornstein, R.A. Watson, G.D. Kaplan, M.J. Effectsof flurazepam and triazolam on neuropsychological performance Perception and Motor Skills 1985 60 47 52
- Snapper, K.J. Seaver, D.A. Schwartz, J.P. An assessment of behavioral tests to detect impaired drivers Springfield VA National Technical Information Service 1981
- Quenault S.W. Development of the method of systematic observation of driver behavior (Report RRL LR 213) Crowthorne UK Road Research Laboratory 1968
- Klebelsberg, D. Biehl, B. Fuhrmann, J. Seydel, U. Fahrverhalten: Beschreibung, Beurteilung und diagnostische Erfassung Kleine Fachbuchreihe 8 Vienna Kura-torium fur Verkehrssicherheit 1970
- Joscelyn, K.B. Donelson, A.C. Jones, R. K. McNair, J.W. Ruschmann, P.A. Drugs and highway safety 1980 (Final Report DOT HS 805 461) Washington US Department of Transportation 1980
- Willette, R.E. Walsh, J.M. Drugs, driving and traffic safety Geneva World Health Organization 1983
- Linnoila, M. Mattila, M.J. Druginteraction on driving skills as evaluated by laboratory tests and by a driving simulator Pharraakopsychiatria 1973 6 127 132
- Kleinknecht, R.A. Donaldson, D. Areview of the effects of diazepam on cognitive and psychomotor performance Journal of Nervous and Mental Disease 1975 161 399 411
- Linnoila, M. Tranquilizersand driving Accident Analysis and Prevention 1976 8 15 19
- Seppälä, T. Linnoila H. Mattila, M. J. Drugs, alcohol and driving Drugs 1979 17 389 408
- Linnoila, M. Benzodiazepinesand performance In Costa, E. The benzodiazepines: from molecular biology to clinical practice New York Raven Press 1983
- O.E.C.D. (Organisation for Economic Cooperation and Development - Road Research Group) New research on the role of alcohol and drugs in road accidents Paris O.E.C.D. 1978
- Wittenborn, J.R. Behavioraltoxicity in normal humans as a model for assessing behavioral toxicity in patients In Lipton, M.A. DiMascio, D. Killam, K, F Psychopharmacology: a generation of progress New York Raven Press 1978
- McNair, D.M. Antianxiety drugs and human performance Archives of General Psychiatry 1973 29 611 617
- Wittenborn, J.R. Effectsof benzodiazepines on psychomotor performance British Journal of Clinical Pharmacology 1979 7 61S 67S
- Hindmarch, I. Psychomotorfunction and psychoactive drugs British Journal of Clinical Pharmacology 1980 10 189 209
- Hindmarch, I. Measuringthe effect of psychoactive drugs on higher brain functions Advances in Human Psychopharmacology 1981 2 99 127
- Landauer A.A. Diazepam and driving ability Medical Journal of Australia 1981 1 624 626
- Walls, H.J. Brownlie, A.R. Drink, drugs and driving 2nd London Sweet and Maxwell 1985
- Nicholson A.N. The use of short and long acting hypnotics in clinical medicine British Journal of Clinical Pharmacology 1981 11 61S 69S
- Johnson, L.C. Chernik, D.A. Sedative-hypnotics and human performance Psycho-pharmacology 1982 76 102 113
- Chan, A.W.K. Effectsof combined alcohol and benzodiazepine: a review Drug and Alcohol Dependence 1984 13 315 341
- Staak, M. Wirkungvon Arznelraitteln auf die Verkehrsttlchtigkeit Wagner H.J. Verkehrsmedizin. Berlin Springer 1984
- Murray, J.B. Effectsof Valium and Librium on human psychomotor and cognitive functions Genetic Psychology Monographs 1984 109 167 197
- Ellinwood, E.H. Heatherley, D.G. Benzodiazepines, the popular minor tranquilizers: dynamics of effect on driving skills Accident Analysis and Prevention 1935 17 283 290
- Biehl, B. Studiesof clobazam and car-driving British Journal of Clinical Pharmacology 1979 7 85S 90S
- de Gier, J.J. 't Hart, B.J. Nelemans, F. A. Bergman H. Psychomotor performance and real driving performance of outpatients receiving diazepam Psychopharmacology 1981 73 340 344
- O'Hanlon, J.F. Haak, T.W. Blaauw, G.J. Riemersma, J.B.J. Diazepamimpairs lateral position control in highway driving Science 1982 217 79 81
- Zimmermann-Tansella, C Tansella, M. Lader, M. Acomparison of the clinical and psychological effects of diazepam and amylobarbitone in anxious patients British Journal of Clinical Pharmacology 1979 7 605 611
- Wetherell A. Individual and group effects of 10 mg diazepam on drivers' ability, confidence and willingness to act in a gap-judging task Psychopharmacology 1979 63 259 267
- Pomara, N. Stanley, B. Block, R. Berchou, R.C. Stanley, M. Greenblatt, D.J. Newton, R.E. Gershon S. Increased sensitivity in the elderly to the central depressant effects of diazepam Journal of Clinical Psychiatry 1985 46 185 187
- Lucki, I. Rickels, K. Geller A.M. Psychomotor performance- following the long-term use of benzodiazepines Psychopharmacology Bulletin 1985 21 93 96
- Joscelyn, K.B. Donelson A.C. Drugs and highway safety: research issues and information needs HSRI Research Review 1978 9 (2) 2 17
- Borkenstein, R.F. Crowther, R.F. Shumate, R.P. Ziel, W.B. Zylman, R. The role of the drinking driver in traffic accidents Bloomington Indiana University 1964
- Schwartz, R.D. Cohn, V.H. Abramson, F. P. Drugs, driving and the law: a prospective review Contemporary Drug Problems 1977 6 283 306
- Joscelyn, K.B. Jones, R.K. Maickel, R.P. Donelson A.C. Drugs and driving; information needs and research requirements Ann Arbor MI Highway Research Institute 1979
- Blackburn, R.R. Woodhouse, E.J. A comparison of drug use in driver fatalities and similarly exposed drivers (Report DOT HS-802 488) Washington National Highway Safety Administration 1977
- Woodhouse, E.J. Theprevalence of drugs in fatally injured drivers Israelstam S. Lambert S. Alcohol, drugs and traffic safety. Toronto Addiction Research Foundation 1975
- Garriott, J.C. DiMaio, V.J.M. Zumwalt, R.E. Petty, C.S. Incidenceof drug and alcohol in fatally injured motor vehicle drivers Journal of Forensic Science 1977 22 383 389
- Missen, A.W. Cleary, W.T. Eng, L. McMillan, S. Diazepam, alcohol and drivers New Zealand Medical Journal 1978 87 275 277
- Missen A.W. Cleary, W.T. Eng, L. McDonald, K.S. Prescriptiondrugs, alcohol and road fatalities New Zealand Medical Journal 1978 88 418 419
- Skegg, D.C.G. Richards S.M. Doll, R. Minortranquillisers and road accidents British Medical Journal 1979 1 917 919
- Honkanen, R. Ertanta, L. Linnoila, M. Alha A. Lukkari, I. Karlsson, M. Kiviluoto, O. Puro, M. Roleof drugs in traffic accidents British Medical Journal 1980 281 1309 1312
- Warren, R. Simpson H. Hilchie, J. Cimbura, G. Lucas, D. Bennett, R. Drugsdetected in fatally injured drivers in the province of Ontario In Goldberg, L. Alcohol, drugs and traffic safety Stockholm Almqvist and Wiksell 1981
- Cimbura, G. Lucas, D.M. Bennett, R.C. Warren, R.A. Simpson H.M. Incidence and toxicological aspects of drugs detected in 484 fatally injured drivers and pedestrians in Ontario Journal of Forensic Science 1982 27 855 867
- Krantz, P. Wannerberg, O. Occurrenceof barbiturate, benzodiazepine, meprobam-ate, methaqualone and phenothiazine in car occupants killed in traffic accidents in the south of Sweden Forensic Science International 1981 18 141 147
- Vine, J. Watson, T.R. Incidenceof drug and alcohol intake in road traffic accident victims Medical Journal of Australia 1983 1 612 615
- Carmody, J. Boyle, R. Butler, P. Douglas, P. Dwyer, D. Patternsof the use of benzodiazepines in Australia Medical Journal of Australia 1977 2 666 668
- MacPherson, R.D. Perl, J. Startner, G.A. Homel, R. Self-reported drug-usage and crash-incidence in breathalyzed drivers Accident Analysis and. Prevention 1984 16 139 148
- Williams, A.F. Peat, M.A. Crouch, D.J. Wells, J.K. Finkle, B.S. Drugsin fatally injured young male drivers Public Health Reports 1985 100 19 25
- Ellinwood, E.H. Linnoila, M. Easier, M. E. Molter, D.W. Onsetof peak impairment after diazepam and after alcohol Clinical Pharmacology and Therapeutics 1981 30 534 538
- Haefely, W. Pole, P. Pieri, L. Schaffner, R. Laurent, J.P. Neuropharmacologyof benzodiazepines: synaptic mechanism and neural basis of action In Costa, E. The benzodiazepines: from molecular biology to clinical practice New York Raven Press 1983
- Mattila, M.J. Palva, E. Seppaia, T. Ostrovskaya, R.U. Actionsand interactions with alcohol of drugs on psychomotor skills: comparison of diazepam and X-hydroxybutyric acid Archives Internationales de Fharmaco-dynamie et de Therapie 1978 234 236 246
- Palva, E.S. Linnoila, M. Routledge, P. Seppälä, T. Actions and interactions of diazepam and alcohol on psychomotor skills in young and middle-aged subjects Acta Pharmacologica et Toxicologica (Copenhagen) 1982 50 363 369
- Berchou, R. Block, R.I. Useof computerized psychomotor testing in determining CNS effects of drugs Perceptual and Motor Skills 1983 57 691 700
- Saario, I. Linnoila, M. Mattila, M.J. Modificationby diazepam or thioridazine of the psychomotor skills related to driving: a sub-acute trial in neurotic out-patients British Journal of Clinical Pharmacology 1976 3 843 848
- Palva, E.S. Linnoila, M. Saario, I. Mattila, M.J. Acuteand subacute effects of diazepam on psychomotor skill: interaction with alcohol Acta Pharmacologica et Toxicologica (Copenhagen) 1979 45 257 264
- Bond, A. Lader, M. Comparativeeffects of diazepam and buspirone on subjective feelings, psychological tests and EEG International Pharmacopsychiatry 1981 16 212 220
- Lader, M. Psychologicaleffects of buspirone Journal of Clinical Psychiatry 1982 43 12 62 67
- Hamilton, M.J. Bush, M. Smith, P. Peck A.W. The effects of bupropion, a new antidepressant drug, and diazepam, and their interaction in man British Journal of Clinical Pharmacology 1982 14 791 797
- Bond A. Lader, M. Acomparison of the psychotropic profiles of tofisopam and diazepam European Journal of Clinical Pharmacology 1982 22 137 142
- Salkind, M.R. Hanks, G.W. Silverstone, J.T. Evaluationof the effects of clobazam, a new 1,5-benzodiazepine, on mood and psychomotor performance in clinically anxious patients in general practice British Journal of Clinical Pharmacology 1979 7 113S 118S
- Bond, A. Lader, M. Shrotriya, R. Comparativeeffects of a repeated dose regime of diazepam and buspirone on subjective ratings, psychological tests and EEC European Journal of Clinical Pharmacology 1983 24 463 467
- Ghoneim, M.K. Mewaldt, S.P. Hinrichs, J.V. Behavioraleffects of oral versus intravenous administration of diazepam Pharmacology, Biochemistry and Behavior 1984 21 231 236
- Jones, D.M. Lewis, M.J. Spriggs, T. L.B. Theeffects of low doses of diazepam on human performance in a group administered task British Journal of Clinical Pharmacology 1978 6 333 337
- Tallone, G. Ghirardi, P. Bianchi, M.C. Ravaccia, F. Bruni, G. Loreti, P. Reactiontime to acoustic or visual stimuli after administration of camazepam and diazepam in man Arzneimittelforschung 1980 30 1021 1024
- Barbee, J.G. Black, I.L. Effectof diazepam on visuomotor reaction time Perceptual and Motor Skills 1985 60 107 110
- Liljequist, R. Linnoila, M. Mattila, M.J. Effectof diazepam and chlorpromazine on memory functions in man European Journal of Clinical Pharmacology 1978 13 339 343
- Borland, R.G. Nicholson A.N. Residual effects of potassium clorazepate, a precursor of nordiazepam British Journal of Clinical Pharmacology 1977 4 86 89
- Willumeit, H.P. Ott, H. Neubert, W. Hemmerling, K.G. Schratzer, M. Fichte, K. Alcoholinteraction of lormetazepam, mepindolol sulphate and diazepam measured by performance on a driving simulator Pharmacopsychiatria 1984 17 36 43
- Linnoila, M. Erwin, C.W. Brendle A. Simpson, D. Psychomotoreffects of diazepam in anxious patients and healthy volunteers Journal of Clinical Psychopharmacology 1983 3 88 96