This content is not included in
your SAE MOBILUS subscription, or you are not logged in.
Towards a Theory of Human Intraspecific Variation for Ergonomics and Human Modeling
Technical Paper
2007-01-2461
ISSN: 0148-7191, e-ISSN: 2688-3627
Annotation ability available
Sector:
Language:
English
Abstract
Human intraspecific variation is a complex problem, but may be better understood by using computational models in tandem with knowledge about the genetic bases of phenotypic traits. These results can be used in a multitude of settings. To move closer to this goal, biologically-realistic mappings between genotype and phenotype are constructed using genetic algorithm and neural network-like models. These models allow for gene-gene and gene-environment interactions to be characterized in the resulting phenotype. Two types of model are introduced: a simple, two-layer model, and a more complex model. The final section will focus on trends of growth and development in relation to relationship to modeling anthropometric traits and other morphological phenomena.
Authors
Citation
Alicea, B., "Towards a Theory of Human Intraspecific Variation for Ergonomics and Human Modeling," SAE Technical Paper 2007-01-2461, 2007, https://doi.org/10.4271/2007-01-2461.Also In
References
- Venter J.G. Adams M.D. Myers E. W. Celera Genomics Sequencing Team (2001). The Sequence of the Human Genome. Science, 291(5507) 1304 1351
- McPherson J.D. International Human Genome Mapping Consortium (2001) A physical map of the human genome. Nature 409 934 941
- Waterston R.H. Lander E.S. Wilson R.K. Chimpanzee Sequencing and Analysis Consortium (2005) Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 437 69 87
- Collins F.S. Green E.D. Guttmacher A.E. Guyer M.S. 2003 A vision for the future of genomics research. Nature 422 835 847
- Carrier D.R. Chase K. Lark K.G. 2005 Genetics of Canid skeletal variation: size and shape of the pelvis Genome Research 15 1825 1830
- Malau-Aduli A.E.O. Niibayashi T. Kojima T. Oshima K. Mizoguchi Y. Komatsu M. 2005 Mapping the QTL for body shape and conformation measurements on BTA1 in Japanese black cattle Animal Science Journal 76 1 19
- Goldberg D.E. 1989 Genetic Algorithms in Search, Optimization and Machine Learning. New York: Addison-Wesley
- Grefenstette J. 1986 Optimization of control parameters for genetic algorithms IEEE Transactions on Systems, Man, and Cybernetics 16 1 122 128
- Gilbert S.F. 1997 Developmental Biology. Sunderland, MA: Sinauer
- Pearson J.C. Lemons D. McGinnis W. 2005 Modulating Hox Gene Functions During Animal Body Patterning Nature Review Genetics 6 12 881
- Mourant A.E. 1980 Linkage equilibrium and disequilibrium in human population studies Annals of Human Biology 7 2 109 114
- Hartl D.L. Clark A.G. 2006 Principles of Population Genetics. Sunderland, MA: Sinauer
- McKinney B.A. Reif D.M. Ritchie M.D. Moore J.H. 2006 Machine Learning for Detecting Gene-Gene Interactions: a review. Applied Bioinformatics 5 2 77 88
- Ewens W.J. 2004 Mathematical Population Genetics. Berlin: Springer
- Ahituv N. Kavaslar N. Schackwitz W. Ustaszewska A. Martin J. Hebert S. Doelle H. Ersoy B. Kryukov G. Schmidt S. Yosef N. Ruppin E. Sharan R. Vaisse C Sunyaev S. Dent R. Cohen J. McPherson R. Pennacchio L.A. 2007 Medical Sequencing at the Extremes of Human Body Mass The American Journal of Human Genetics 80 779 791
- Wu R. Hou W. 2006 A hyperspace model to decipher the genetic architecture of developmental processes: autometry meets ontogeny. Genetics 172 1 627 637
- Jantz L.M. Jantz R.L. 1999 Secular change in long bone length and proportion in the United States, 1800-1970 American Journal of Physical Anthropology 110 1 57 67
- Magnenat-Thalmann N. Seo H. Cordier F. 2004 Automatic modeling of virtual humans and body clothing Journal of Computer Science and Technology 19 5 575 584
- Seo H. Yahia-Cherif L. Goto T. Magnenat-Thalmann N. 2002 GENESIS: Generation of e-population based on statistical information Proceedings of the Computer Animation, IEEE Computer Society 81
- Domaracki M. Stephan C.N. 2006 Facial soft tissue thickness in Australian adult cadavers Journal of Forensic Sciences 51 1 5