This content is not included in
your SAE MOBILUS subscription, or you are not logged in.
Shear Properties of Brain Tissue over a Frequency Range Relevant for Automotive Impact Situations: New Experimental Results
Technical Paper
2004-22-0011
Annotation ability available
Sector:
Language:
English
Abstract
This research aims at improving the definition of the shear linear material properties of brain tissue. A comparison between human and porcine white and gray matter samples was carried out over a new large frequency range associated with both traffic road and non-penetrating ballistic impacts. Oscillatory experiments were performed by using an original custom-designed oscillatory shear testing device. The findings revealed that no significant difference occurred between the linear viscoelastic behavior of the porcine and the human brain tissues. On the average, the storage modulus (G′) and the loss modulus (G″) of the white matter increased respectively from 2.1 ± 0.9 kPa to 16.8 ± 2.0 kPa and from 0.4 ± 0.2 kPa to 18.7 ± 2.3 kPa between 0.1 and 6300 Hz at 37°C. In addition, the gray and white matter behaviors seemed to be similar at small strains. The reliability of the data and the robustness of the experimental protocol were checked using a standard rheometer (Bohlin C-VOR 150). A good agreement was found between the data obtained in the frequency and time field. As a result, the linear relaxation modulus was determined over an extensive time range (from 10−5 s to 300 s). In a first approach, the nonlinear behavior of brain tissue was studied using stress relaxation tests. Brain tissue showed significant shear softening for strains above 1% and the time relaxation behavior was independent of the applied strain. On this basis, a visco-hyperelastic model was proposed using the generalized Maxwell model and the Ogden hyperelastic model. These models respectively describe the linear relaxation modulus and the strain dependence of the shear stress.
Recommended Content
Authors
- Stéphane Nicolle - Institut of Mechanical Engineering of Fluids and Solids, Louis Pasteur University, Strasbourg, France
- Mourad Lounis - Institut of Mechanical Engineering of Fluids and Solids, Louis Pasteur University, Strasbourg, France
- Rémy Willinger - Institut of Mechanical Engineering of Fluids and Solids, Louis Pasteur University, Strasbourg, France
Topic
Citation
Nicolle, S., Lounis, M., and Willinger, R., "Shear Properties of Brain Tissue over a Frequency Range Relevant for Automotive Impact Situations: New Experimental Results," SAE Technical Paper 2004-22-0011, 2004, https://doi.org/10.4271/2004-22-0011.Also In
References
- Arbogast, K.B. Margulies, S.S. 1997 Regional differences in mechanical properties of the porcine central nervous system Proc. Of the 41st Stapp Car Crash Conf, SAE 973336 293 300
- Arbogast, K.B. Margulies, S.S. 1998 Material characterization of the brainstem from oscillatory shear tests Journal of Biomechanics 31 801 807
- Arbogast, K.B. Meaney, D.F. 1995 Biomechanical charcterization of the constitutive relationship of the brainstem Proc. Of the Society of Automotive Engineers 153 159
- Arbogast, K.B. Thibault, K.L. Pinheiro, B.S. Winey, K.I. Margulies, S.S. 1997 A high-frequency shear device for testing soft biological tissues Journal of Biomechanics 30 7 757 759
- Bilston, L.E. Liu, Z. Phan-Thien, N. 1997 Linear viscoelastic properties of bovine brain tissue in shear Biorheology 34 377 385
- Brands, D.W.A. 2002 Predicting brain mechanics during closed head imapect - Numerical and constitutive aspects Ph.D. Dissertation Thesis University of Eindhoven Eindhoven, The Netherlands
- Brands, D.W.A. Bovendeerd, P.H. Peters, G.W.M. 1999 Comparison of the dynamic behaviour of brain tissue and two model materials Proc. Of the 43rd Stapp Car Crash Conf 313 320
- Brands, D.W.A. Bovendeerd, P.H. Peters, G.W.M. 2000a Finite shear behaviour of brain tissue under impact loading ASME-WAM, Conf. on Crashworthiness, Occupant Protection and Biomechanics in Transportation Systems 175 188
- Brands, D.W.A. Bovendeerd, P.H. Peters, G.W.M. 2000b The large shear strain dynamic behaviour of in-vitro porcine brain tissue and a silicone gel model material Stapp Car Crash Journal 44 249 260
- Darvish, K.K. Crandall, J.R. 2001 Nonlinear viscoelastic effects in oscillatory shear deformation of brain tissue Medical Engineering & Physics 23 633 645
- Donnelly, B. Medige, J. 1997 Shear properties of human brain tissue Journal of Biomechanical Engineering 119 423 432
- Estes, M.S. McElhaney, J.H. 1970 Response of brain tissue to compressive loading Proc. Of the 4th ASME Biomechanics Conf, 70-BHF-13
- Fallenstein, G.T. Hulce, V.D. 1969 Dynamic mechanical properties of human brain tissue Journal of Biomechanics 2 217 226
- Ferry, J.D. 1980 Viscoelastic Properties of Polymers 3rd John Wiley & Sons New York
- Finfer, S.R. Cohen, J. 2001 Severe traumatic brain injury Resuscitation 48 77 90
- Galford, J. E. McElhaney, J.H. 1970 A viscoelastic study of scalp, brain and dura Journal of Biomechanics 3 211 221
- Guillaume, A. Osmont, D. Gaffie, D. Sarron, J.-C. Quandieu, P. 1997 Effects of perfusion on the mechanical behavior of the brain exposed to hypergravity Journal of Biomechanics 30 4 383 389
- Gurdjian, E.S. Lissner, H.R. Patrick, L.M. 1962 Protection of the head and neck in sports Journal of Am. Med. Ass. 182 502 512
- Hardy, W.N. Foster, C.D. Mason, M.J. Yang, K.H. King, A.I Tashman, S. 2001 Investigation of head injury mechanisms using neutral density technology and high-speed biplanar X-ray Stapp Car Crash Journal 45 337 368
- Hickling, R. Wenner, M.L. 1973 Mathematical model of a head subjected to an axisymmetric impact Journal of Biomechanics 6 115 132
- Jennett, B. 1996 Epidemiology of head injury J Neurol Neurosurg Psychiatry 60 362 369
- Kang, H.S. Willinger, R. Diaw, B.D. 1996 Dynamic intracranial pressure during head impact Mécanique Industrielle et Matériaux, Revue du GAMI 49 5 237 239
- Kleiven, S. Hardy, W.N. 2002 Correlation of an FE model of the human head with local brain motion - Consequences for injury prediction Stapp Car Crash Journal 46 123 144
- Kruse, S.A. Dresner, M.A. Rossman, P.J. Felmlee, J.P. Jack, C.R. Ehman, R.L. 1999 ‘Palpation of the brain’ using magnetic resonance elastography Proc. Of the 7th Int. Soc. Magn. Reson. Med. 258
- Lin, S-C. Shieh, S-J. Grimm, M.J. 1997 Ultrasonic measurements of brain tissu properties Proc. Of the Symposium of the Centers for Disease Control and Prevention 27 31
- Ljung, C. 1975 A model for brain deformation due to rotation of the skull Journal of Biomechanics 8 263 274
- Manduca, A. Oliphant, T.E. Dresner, M.A. Mahowald, J.L. Kruse, S.A. Amromin, E. Felmlee, J.P. Greenleaf, R.L. Ehman, R.L. 2001 Magnetic resonance elastography: Non-invasive mapping of tissue elasticity Medical Image Analysis 5 237 254
- McElhaney, J.H. Melvin, J.W. Roberts, V.L. Portnoy, H.D. 1973 Dynamic characteristics of the tissues of the head Perspectives in Biomedical Engineering Kenedi R.M. 215 222 MacMillan Press London
- McIlwain, H 1966 Biochemistry and the Central Nervous System 3rd Ed. Churchill London
- Mendis, K.K. Stalnaker, R.L. Advani, S.H. 1995 A constitutive relationship for large deformation finite element modeling of brain tissue Journal of Biomechanical Engineering 117 279 285
- Miller, K. Chinzei, K. 1997 Constitutive modelling of brain tissue: experiment and theory Journal of Biomechanics 30 11/12 1115 1121
- Miller, K. Chinzei, K. Orssengo, G. Bednarz, P. 2000 Mechanical properties of brain tissue in-vivo: experiment and computer simulation Journal of Biomechanics 33 1369 1376
- Murray, G.D. Teasdale, G.M. Braakman, R. Cohadon, F. Dearden, M. lannotti, F. Karimi, A. Lapierre, F. Maas, A. Ohman, J. Persson, L. Servadei, F. Stocchetti, N. Trojanowski, T. Unterberg, A. 1999 The European Brain Injury Consortium Survey of Head Injuries Acta Neurochirurgica 141 223 236
- Ogden, R.W. 1972 Large deformation isotropic elasticity - on the correlation of theory and experiment for incompressible rubberlike solids Proc. R. Soc. Lond. 565 584
- Peters, G.W.M. Meulman, J.H. Sauren, A.A.H.J. 1997 The applicability of the time/temperature superposition principle to the brain tissue Biorheology 34 2 127 138
- Pieropaoli, C. Basser, P. 1996 Quantitative assessment of diffusion anisotropy Magnetic Resonance in Medicine 36 893 906
- Prange, M.T. Meaney, D.F. S.S., Margulies 2000 Defining brain mechanical properties: effects of region, direction and species Stapp Car Crash Journal 44 205 213
- Roths, T 2001 GENEREG: A program for the calculation of the solution of nonlinear and parametric inverse problems by means of a generalised regularization method. Freiburg Germany http://www.fmf.uni-freiburg.de/~info/
- Shuck, L.Z. Advani, S.H. 1972 Rheological response of human brain tissue in shear ASME Journal of Basic Engineering 94 905 911
- Soskey, P.R. Winter H.H. 1984 Large step shear strain experiments with parallel-disk rotational rheometers Journal of Rheology 28 5 625 645
- Takhounts, E.G. 1998 The experimental determination of constitutive equations of human and bovine brain tissue PhD Dissertation Thesis University of Virginia
- Takhounts, E.G. Crandall, J.R. Darvish, K.K. 2003 On the importance of brain tissue under large deformations Stapp Car Crash Journal 47 79 92
- Thibault, K.L. Margulies, S.S. 1998 Age-dependant material properties of the porcine brain cerebrum: effect on pediatric inertial head injury criteria Journal of Biomechanics 31 1119 1126
- Thurman, D. Alverson, C. Dunn, K. Guerrero, J. Sniezek, J. 1999 Traumatic brain injury in the United States: a public health perspective Journal of Head Trauma and Rehabilitation 14 6 602 615
- Zhang, L. Yang, K. King, A.I. 2001a Comparison of brain responses between frontal and lateral impacts by finite element modelling Journal of Neurotrauma 18 1 21 30
- Zhang, L. Yang, K.H. Dwarampudi, R. Omori, K. Li, T. Chang, K. Hardy, W.N. Khalil, T.B. King, A.I. 2001b Recent advances in brain injury research: A new human head model development and validation Stapp Car Crash Journal 45 369 393